Fosnetupitant / Palonosetron Side Effects

Medically reviewed by Drugs.com. Last updated on May 26, 2024.

Applies to fosnetupitant / palonosetron: intravenous powder for solution, intravenous solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that it is working properly and to check for unwanted effects.

This medicine may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Other side effects

Some side effects of fosnetupitant / palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects

Along with its needed effects, fosnetupitant/palonosetron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fosnetupitant / palonosetron:

For healthcare professionals

Applies to fosnetupitant / palonosetron: intravenous powder for injection, intravenous solution.

Gastrointestinal adverse events

• Frequency not reported: Constipation, dyspepsia

Palonosetron:

• Common (1% to 10%): Constipation, dyspepsia^[Ref]

Other

• Frequency not reported: Asthenia, fatigue

Palonosetron:

• Common (1% to 10%): Asthenia, fatigue^[Ref]

Nervous system

• Frequency not reported: Headache, serotonin syndrome

Palonosetron:

• Common (1% to 10%): Headache^[Ref]

Dermatologic

• Frequency not reported: Erythema

Palonosetron:

• Common (1% to 10%): Erythema^[Ref]

Hepatic

Palonosetron:

• Uncommon (0.1% to 1%): Elevated AST, elevated ALT, elevated total bilirubin^[Ref]

Approximately 0.6% of patients given 0.5 mg of palonosetron developed AST greater than 3 times the upper limit of normal (ULN) and/or ALT greater than 3 x ULN with total bilirubin greater than ULN. Approximately 0.2% of patients given the same dose of palonosetron developed AST greater than 10 x ULN and/or ALT greater than 10 x ULN with total bilirubin greater than ULN, and approximately 0.1% of patients developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN.

Approximately 0.3% of patients given oral formulations of netupitant-palonosetron developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than ULN, and AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN occurred in up to 0.1% of patients.^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions^[Ref]

See also:

Further information

Fosnetupitant/palonosetron side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer