Fosnetupitant / Palonosetron Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 22, 2024.

Applies to fosnetupitant / palonosetron: intravenous powder for solution, intravenous solution.

Other side effects

Some side effects of fosnetupitant / palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• headache
• unusual tiredness or weakness

Less common side effects

• constipation
• heartburn
• indigestion
• stomach discomfort, upset, or pain

Serious side effects

Along with its needed effects, fosnetupitant/palonosetron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fosnetupitant / palonosetron:

Incidence not known

• agitation
• confusion
• cough or hoarseness
• dizziness
• fast heartbeat
• fever
• hearing or seeing things that are not there
• hives, itching, skin rash
• irritation
• joint pain, stiffness or swelling
• muscle twitching
• overactive reflexes
• poor coordination
• redness of the skin
• shivering
• sweating
• swelling of the eyelids, face, lips, hands, or feet
• tightness in the chest
• trembling or shaking
• trouble breathing or swallowing

For healthcare professionals

Applies to fosnetupitant / palonosetron: intravenous powder for injection, intravenous solution.

Gastrointestinal adverse events

• Frequency not reported: Constipation, dyspepsia

Palonosetron:

• Common (1% to 10%): Constipation, dyspepsia^[Ref]

Other

• Frequency not reported: Asthenia, fatigue

Palonosetron:

• Common (1% to 10%): Asthenia, fatigue^[Ref]

Nervous system

• Frequency not reported: Headache, serotonin syndrome

Palonosetron:

• Common (1% to 10%): Headache^[Ref]

Dermatologic

• Frequency not reported: Erythema

Palonosetron:

• Common (1% to 10%): Erythema^[Ref]

Hepatic

Palonosetron:

• Uncommon (0.1% to 1%): Elevated AST, elevated ALT, elevated total bilirubin^[Ref]

Approximately 0.6% of patients given 0.5 mg of palonosetron developed AST greater than 3 times the upper limit of normal (ULN) and/or ALT greater than 3 x ULN with total bilirubin greater than ULN. Approximately 0.2% of patients given the same dose of palonosetron developed AST greater than 10 x ULN and/or ALT greater than 10 x ULN with total bilirubin greater than ULN, and approximately 0.1% of patients developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN.

Approximately 0.3% of patients given oral formulations of netupitant-palonosetron developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than ULN, and AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN occurred in up to 0.1% of patients.^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions^[Ref]

Further information

Fosnetupitant/palonosetron side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer