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Fareston Side Effects

Generic Name: toremifene

Note: This page contains information about the side effects of toremifene. Some of the dosage forms included on this document may not apply to the brand name Fareston.

In Summary

Common side effects of Fareston include: hot flash, nausea, vaginal discharge, and diaphoresis. Other side effects include: dizziness, edema, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to toremifene: oral tablet

In addition to its needed effects, some unwanted effects may be caused by toremifene (the active ingredient contained in Fareston). In the event that any of these side effects do occur, they may require medical attention.

Also, because of the way this medicine acts on the body, there is a chance that it might cause other unwanted effects that may not occur until months or years after the medicine is used. Some patients who have used toremifene have developed cancer of the uterus (womb), although it is not known for sure if it was caused by the medicine. Discuss this possible effect with your doctor.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking toremifene:

Less common:
  • Abdominal or stomach pain
  • anxiety
  • arm, back, or jaw pain
  • blurred vision
  • change in vaginal discharge
  • changes in skin color
  • changes in vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • constipation
  • cough
  • decreased urine output
  • depression
  • dilated neck veins
  • dizziness or lightheadedness
  • dry mouth
  • extreme fatigue
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • inability to speak incoherent speech
  • increased urination
  • irregular breathing
  • irregular heartbeat
  • loss of appetite
  • metallic taste
  • muscle weakness
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • pain or feeling of pressure in the pelvis
  • pain, tenderness, or swelling of the foot or leg
  • seizures
  • severe or sudden headache
  • shortness of breath
  • slurred speech
  • sudden shortness of breath or troubled breathing
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • temporary blindness
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • thirst
  • tightness in the chest
  • troubled breathing
  • unusual tiredness
  • vaginal bleeding
  • vomiting
  • weakness in the arm and/or leg on one side of the body, sudden and severe
  • weight gain
  • weight loss
  • wheezing
Rare
  • Chest pain
Incidence not known:
  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chills
  • clay-colored stools
  • dark urine
  • dizziness
  • fever
  • headache
  • itching
  • painful or difficult urination
  • pinpoint red spots on the skin
  • rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with toremifene may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Blindness
  • decreased vision
  • dry eyes
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • sweating
  • white or brownish vaginal discharge
Less common:
  • Bone pain
  • changes in vision
  • double vision
  • eye pain
  • tearing
Incidence not known:
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, or scaly skin
  • depression
  • difficulty having a bowel movement (stool)
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • feeling unusually cold
  • hair loss
  • itching skin
  • lack or loss of strength
  • partial or slight paralysis
  • sensation of spinning
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • thinning of the hair
  • trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to toremifene: oral tablet

General

Adverse drug reactions are primarily due to the anti-estrogenic actions of this drug and typically occur at the beginning of treatment.[Ref]

Cardiovascular

Very common (10% or more): Hot flashes/flushes (35%)
Common (1% to 10%): Myocardial infarction, arrhythmia, cardiac failure, thrombophlebitis, thrombosis
Uncommon (0.1% to 1%): Angina pectoris
Frequency not reported: QT/QTc interval prolongation[Ref]

Dermatologic

Very common (10% or more): Sweating (20%)
Common (1% to 10%): Rash, pruritus/itching
Uncommon (0.1% to 1%): Skin discoloration
Rare (less than 0.1%): Dermatitis, alopecia[Ref]

Hepatic

Very common (10% or more): Elevated AST (19%), elevated alkaline phosphatase (19%)
Common (1% to 10%): Elevated bilirubin
Rare (less than 0.1%): Jaundice
Very rare (less than 0.01%): Hepatitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (14%)
Common (1% to 10%): Vomiting
Uncommon (0.1% to 1%): Constipation[Ref]

Genitourinary

Very common (10% or more): Vaginal discharge/leukorrhea (13%)
Common (1% to 10%): Vaginal/uterine bleeding
Uncommon (0.1% to 1%): Endometrial hypertrophy
Rare (less than 0.1%): Endometrial polyps
Very rare (less than 0.01%): Endometrial hyperplasia[Ref]

Ocular

Very common (10% or more): Cataracts (10%)
Common (1% to 10%): Dry eyes, abnormal visual fields, corneal keratopathy, glaucoma, abnormal vision/diplopia
Uncommon (0.1% to 1%): Reversible corneal opacity (corneal verticillata/verticulata)[Ref]

Metabolic

Common (1% to 10%): Hypercalcemia
Uncommon (0.1% to 1%): Anorexia, increased weight, appetite loss[Ref]

Nervous system

Common (1% to 10%): Dizziness, cerebrovascular accident/transient ischemic attack
Uncommon (0.1% to 1%): Paresis, tremor, vertigo, headache
Rare (less than 0.1%): Stiffness
Frequency not reported: Rigors[Ref]

Other

Common (1% to 10%): Edema, pain, fatigue
Uncommon (0.1% to 1%): Asthenia, chest pain[Ref]

Psychiatric

Common (1% to 10%): Depression
Uncommon (0.1% to 1%): Insomnia
Rare (less than 0.1%): Emotional lability[Ref]

Respiratory

Common (1% to 10%): Pulmonary embolism
Uncommon (0.1% to 1%): Dyspnea[Ref]

Musculoskeletal

Uncommon (0.1% to 1%): Back pain[Ref]

Hematologic

Rare (less than 0.1%): Leukopenia, thrombocytopenia
Frequency not reported: Anemia[Ref]

Oncologic

Very rare (less than 0.01%): Endometrial cancer
Frequency not reported: Tumor flare[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Fareston (toremifene)." Schering Laboratories, Kenilworth, NJ.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for Fareston may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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