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Eye Itch Relief Side Effects

Generic name: ketotifen ophthalmic

Medically reviewed by Last updated on Nov 30, 2022.

Note: This document contains side effect information about ketotifen ophthalmic. Some dosage forms listed on this page may not apply to the brand name Eye Itch Relief.


Common side effects of Eye Itch Relief include: conjunctival injection, headache, and rhinitis. Continue reading for a comprehensive list of adverse effects.

Applies to ketotifen ophthalmic: ophthalmic solution.

Serious side effects of Eye Itch Relief

Along with its needed effects, ketotifen ophthalmic (the active ingredient contained in Eye Itch Relief) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking ketotifen ophthalmic:

More common

Less common

  • Eye discharge
  • eye discomfort
  • eye pain
  • hives
  • increased itching of eyes
  • rash.

Other side effects of Eye Itch Relief

Some side effects of ketotifen ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Burning or stinging of eyes
  • dry eyes
  • eyelid disorder
  • eye sensitivity to light
  • fever, tiredness, achiness, and sore throat
  • increase in size of pupils
  • sore throat
  • tearing.

For Healthcare Professionals

Applies to ketotifen ophthalmic: ophthalmic solution.


Common (1% to 10%): Irritation, pain, punctate keratitis, punctate corneal epithelial erosion

Uncommon (0.1% to 1%): Blurred vision, dry eye, eyelid disorder, conjunctivitis, photophobia, conjunctival hemorrhage

Postmarketing reports: Swelling, eyelid pruritus, edema[Ref]

Ketotifen instillation was associated with mild to moderate burning or stinging in 98% of patients (n=35) in one trial.[Ref]

Nervous system

Uncommon (0.1% to 1%): Headache, somnolence

Postmarketing reports: Dizziness[Ref]


Postmarketing reports: Exacerbation of asthma[Ref]


The most commonly reported adverse effects have included eye irritation, eye pain, punctate keratitis, and punctate corneal epithelial erosion.[Ref]


Uncommon (0.1% to 1%): Rash, eczema, urticaria

Postmarketing reports: Contact dermatitis, facial edema, exacerbation of eczema[Ref]


Uncommon (0.1% to 1%): Dry mouth[Ref]


Uncommon (0.1% to 1%): Hypersensitivity, allergic reactions

Postmarketing reports: Exacerbation of preexisting allergic conditions[Ref]


1. Yanni JM, Stephens DJ, Miller ST, Weimer LK, Graff G, Parnell D, Lang LS, Spellman JM, Brady MT, Gamache DA "The in vitro and in vivo ocular pharmacology of olopatadine (AL- 4943A), an effective anti-allergic/antihistaminic agent." J Ocul Pharmacol Ther 12 (1996): 389-400

2. "Product Information. Zaditor (ketotifen ophthalmic)." Ciba Vision Ophthalmics (2001):

3. Artal MN, Luna JD, Discepola M "A forced choice comfort study of olopatadine hydrochloride 0.1% versus ketotifen fumarate 0.05%." Acta Ophthalmol Scandinavica 78 (2000): 64-5

4. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.