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Exemestane Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 22, 2023.

Applies to exemestane: oral tablet.

Serious side effects of Exemestane

Along with its needed effects, exemestane may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking exemestane:

More common

Less common

Incidence not known

Other side effects of Exemestane

Some side effects of exemestane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to exemestane: oral tablet.


Very common (10% or more): Arthralgia (28.8%)

Common (1% to 10%): Pain in limb, back pain, osteoarthritis, myalgia, pathological fracture, hypoesthesia, skeletal pain, osteoporosis, muscle cramp

Uncommon (0.1% to 1%): Osteoporotic fracture[Ref]


The most commonly reported side effects were hot flushes, arthralgia, and fatigue.[Ref]


Common (1% to 10%): Infection[Ref]


Very Common (10% or more): Nausea (up to 18%), abdominal pain (up to 11%)

Common (1% to 10%): Diarrhea, vomiting, constipation, dyspepsia

Uncommon (0.1% to 1%): Gastric ulcers[Ref]


Very common (10% or more): Increased sweating (17.8%), alopecia (15.1%)

Common (1% to 10%): Dermatitis

Postmarketing reports: Urticaria, pruritus, acute generalized exanthemos pustulosis[Ref]


Very common (10% or more): Hot flushes (up to 32.9%), Hypertension (15.1%)

Common (1% to 10%): Lymphedema, chest pain

Uncommon (0.1% to 1%): Thromboembolism, myocardial infarction[Ref]


Very common (10% or more): Elevation of liver function tests (including enzymes, bilirubin, and alkaline phosphatase)

Postmarketing reports: Hepatitis including cholestatic hepatitis[Ref]


Very common (10% or more): Insomnia (13.7%)

Common (1% to 10%): Depression, anxiety, confusion[Ref]

Nervous system

Very common (10% or more): Headache (13.6%), dizziness (10%)

Common (1% to 10%): Paresthesia, carpal tunnel syndrome

Uncommon (0.1% to 1%): Somnolence, neuropathy[Ref]


Very common (10% or more): Dyspnea

Common (1% to 10%): Coughing, bronchitis, sinusitis, upper respiratory tract infection, pharyngitis, rhinitis[Ref]


Common (1% to 101%): Visual disturbances[Ref]


Common (1% to 10%): Other primary cancer[Ref]


Postmarketing reports: Hypersensitivity[Ref]


Very common (10% or more): Fatigue (up to 22.2%), pain (13%)

Common (1% to 10%): Edema, influenza-like symptoms, fever, generalized weakness, pain at tumor sites, asthenia, peripheral edema[Ref]


Common (1% to 10%): Increased appetite, anorexia, hypercholesterolemia[Ref]


Very common (10% or more): Gynecological (10.5%)

Common (1% to 10%): Urinary tract infection, vaginal hemorrhage

Uncommon (0.1% to 1%): Uterine polyp, uterine polydectomy

Rare (less than 0.1%): Endometrial hyperplasia[Ref]


Very common (10% or more): Decrease in lymphocytes (20%)

Uncommon (0.1%to 1%): Thrombocytopenia, leucopenia[Ref]

Frequently asked questions


1. Product Information. Aromasin (exemestane). Pharmacia and Upjohn. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.