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Evomela Side Effects

Generic name: melphalan

Medically reviewed by Drugs.com. Last updated on Oct 14, 2024.

Note: This document provides detailed information about Evomela Side Effects associated with melphalan. Some dosage forms listed on this page may not apply specifically to the brand name Evomela.

Applies to melphalan: oral tablet.

Other dosage forms:

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Severe bone marrow suppression with resulting infection or bleeding may occur.

Melphalan is leukemogenic in humans.

Melphalan produces chromosomal aberrations in vitro and in vivo and, therefore, should be considered potentially mutagenic in humans.

Along with their needed effects, medicines like melphalan (the active ingredient contained in Evomela) can sometimes cause unwanted effects such as blood problems and other side effects. These and others are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Serious side effects of Evomela

Along with its needed effects, melphalan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking melphalan:

Less common side effects

  • black, tarry stools
  • blood in urine or stools
  • cough or hoarseness, accompanied by fever or chills
  • fast or irregular heart beat
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • painful or difficult urination, accompanied by fever or chills
  • pinpoint red spots on skin
  • shortness of breath
  • skin rash or itching (sudden)
  • troubled breathing
  • unusual bleeding or bruising

Rare side effects

Other side effects of Evomela

Some side effects of melphalan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • nausea and vomiting

For healthcare professionals

Applies to melphalan: injectable powder for injection, intravenous powder for injection, oral tablet.

Hematologic adverse events

thrombocytopenia, anemia)

Oncologic

Respiratory

Dermatologic

Cardiovascular

Gastrointestinal

Hepatic

Hypersensitivity

Other

Renal

Local

Musculoskeletal

References

1. (2019) "Product Information. Alkeran (melphalan)." ApoPharma USA Inc

2. (2019) "Product Information. Melphalan (melphalan)." Actavis U.S. (Alpharma USPD)

Further information

Evomela side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.