Ergotamine Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 21, 2024.

Applies to ergotamine: oral tablets, rectal suppositories, sublingual tablets.

Side effects include:

Nausea, vomiting, abdominal pain, numbness and tingling of the fingers and toes, muscle pain in the extremities, weakness in the legs.

For healthcare professionals

Applies to ergotamine: compounding powder, sublingual tablet.

General adverse events

The most commonly reported adverse effects have included nausea and vomiting.^[Ref]

Nervous system

• Rare (less than 0.1%): Cerebral ischemia
• Frequency not reported: Paresthesias, numbness, weakness

Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.

Cardiovascular

• Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes, gangrene, transient tachycardia, bradycardia, hypertension

Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.

Gastrointestinal

• Frequency not reported: Nausea, vomiting

Musculoskeletal

• Frequency not reported: Musculoskeletal aches, pains, and cramps

Other

• Frequency not reported: Vertigo

Hypersensitivity

• Frequency not reported: Localized edema, itching

See also:

Further information

Ergotamine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer