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Ergotamine Side Effects

For the Consumer

Applies to ergotamine: oral tablets, rectal suppositories, sublingual tablets

Side effects include:

Nausea, vomiting, abdominal pain, numbness and tingling of the fingers and toes, muscle pain in the extremities, weakness in the legs.

For Healthcare Professionals

Applies to ergotamine: compounding powder, sublingual tablet

General

The most commonly reported adverse effects have included nausea and vomiting.[Ref]

Cardiovascular

Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.

Nervous system

Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.

Cardiovascular

Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes, gangrene, transient tachycardia, bradycardia, hypertension

Nervous system

Rare (less than 0.1%): Cerebral ischemia

Frequency not reported: Paresthesias, numbness, weakness

Gastrointestinal

Frequency not reported: Nausea, vomiting

Musculoskeletal

Frequency not reported: Musculoskeletal aches, pains, and cramps

Other

Frequency not reported: Vertigo

Hypersensitivity

Frequency not reported: Localized edema, itching

References

1. "Product Information. Ergomar (ergotamine)." Rosedale Therapeutics, Bristol, TN.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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