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Ergotamine Side Effects

For the Consumer

Applies to ergotamine: oral tablets, rectal suppositories, sublingual tablets

Side effects include:

Nausea, vomiting, abdominal pain, numbness and tingling of the fingers and toes, muscle pain in the extremities, weakness in the legs.

For Healthcare Professionals

Applies to ergotamine: compounding powder, sublingual tablet


The most commonly reported adverse effects have included nausea and vomiting.[Ref]


Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.

Nervous system

Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.


Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes, gangrene, transient tachycardia, bradycardia, hypertension

Nervous system

Rare (less than 0.1%): Cerebral ischemia
Frequency not reported: Paresthesias, numbness, weakness


Frequency not reported: Nausea, vomiting


Frequency not reported: Musculoskeletal aches, pains, and cramps


Frequency not reported: Vertigo


Frequency not reported: Localized edema, itching


1. "Product Information. Ergomar (ergotamine)." Rosedale Therapeutics, Bristol, TN.

Some side effects of ergotamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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