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Ergotamine use while Breastfeeding

Drugs containing Ergotamine: Cafergot, Cafatine, Ergomar, Bellergal-S, Migergot, Wigraine, Ercaf, Spastrin, Bellaphen-S, Duragal-S, Show all 26 »Cafetrate, Bellamine S, Eperbel-S, Bellaspas, Ergocaf-PB, Migracet-PB, Ergocomp-PB, Micomp-PB, Cafatine PB, E-Caff P-B, ErgocaffPB, Belcomp-PB, Bel-Phen-Ergot, Bellamine, Bellamor, Bel-Tabs

Ergotamine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Because there is limited published experience with ergotamine during breastfeeding and it might cause adverse effects in the infant, most authorities consider ergotamine to be undesirable to use during nursing.[1][2]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A study in which ergotamine was administered to mothers of newborns immediately postpartum in a dose of 1 mg 3 times daily for 6 days found no effect on weight gain in the breastfed infants.[3] Milk intake, and therefore infant dosage, might have been minimal during the first few days before the mothers' milk came in fully.

Effects on Lactation and Breastmilk

Thirty women who delivered fullterm infants received a single intramuscular dose of methylergonovine 0.2 mg after delivery, followed by oral ergotamine 1 mg 3 times daily for 6 days. Compared to 28 women who delivered fullterm infants and received no ergot derivatives, there was no difference in the milk production, as measured by weight differences before and after nursing, between the 2 groups during the first 6 days postpartum.[3]

Alternate Drugs to Consider

Sumatriptan, Eletriptan

References

1. Moretti ME, Lee A, Ito S. Which drugs are contraindicated during breastfeeding? Can Fam Physician. 2000;46:1753-7. PMID: 11013791

2. WHO Department of Child and Adolescent Health and Development. Breastfeeding and maternal medication. Recommendations for drugs in the eleventh WHO model list of essential drugs. 2002.

3. Jolivet A, Robyn C et al. [Effect of ergot alkaloid derivatives on milk secretion in the immediate postpartum period]. J Gynecol Obstet Biol Reprod (Paris). 1978;7:129-34. PMID: 641312

Ergotamine Identification

Substance Name

Ergotamine

CAS Registry Number

113-15-5

Drug Class

Adrenergic Alpha-Agonists

Analgesics, Non-Narcotic

Ergot Alkaloids

Vasoconstrictor Agents

Administrative Information

LactMed Record Number

458

Last Revision Date

20140708

Disclaimer

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