Ergotamine use while Breastfeeding
Medically reviewed by Drugs.com. Last updated on May 8, 2022.
Drugs containing Ergotamine: Cafergot, Migergot, Bellergal-S, Duragal-S, Ergomar, Belcomp-PB, Cafatine PB, Micomp-PB, Ergocomp-PB, Ergocaf-PB, Show all 26 »Migracet-PB, E-Caff P-B, ErgocaffPB, Bellamor, Bellamine, Bel-Phen-Ergot, Bellaspas, Bel-Tabs, Bellamine S, Bellaphen-S, Spastrin, Eperbel-S, Wigraine, Cafetrate, Ercaf, Cafatine
Ergotamine Levels and Effects while Breastfeeding
Summary of Use during Lactation
There is limited published experience with ergotamine during breastfeeding and it might cause adverse effects in the infant and decrease milk supply. Most authorities consider ergotamine to be contraindicated during nursing.[1-5]
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
A study in which ergotamine was administered to mothers of newborns immediately postpartum in a dose of 1 mg 3 times daily for 6 days found no effect on weight gain in the breastfed infants. Milk intake, and therefore infant dosage, might have been minimal during the first few days before the mothers' milk came in fully.
Effects on Lactation and Breastmilk
Thirty women who delivered fullterm infants received a single intramuscular dose of methylergonovine 0.2 mg after delivery, followed by oral ergotamine 1 mg 3 times daily for 6 days. Compared to 28 women who delivered fullterm infants and received no ergot derivatives, there was no difference in the milk production, as measured by weight differences before and after nursing, between the 2 groups during the first 6 days postpartum.
Moretti ME, Lee A, Ito S. Which drugs are contraindicated during breastfeeding? Can Fam Physician. 2000;46:1753–7. [PMC free article: PMC2145042] [PubMed: 11013791]
WHO Department of Child and Adolescent Health and Development. Breastfeeding and maternal medication. Recommendations for drugs in the eleventh WHO model list of essential drugs. 2002. http://www
.who.int/child _adolescent_health /documents/55732/en/
Davanzo R, Bua J, Paloni G, et al. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014;70:1313–24. [PubMed: 25217187]
MacGregor EA. Migraine in pregnancy and lactation. Neurol Sci. 2014;35 Suppl 1:61–4. [PubMed: 24867839]
Anderson PO. Migraine drug therapy during breastfeeding. Breastfeed Med. 2019;14:445–7. [PubMed: 31347910]
Jolivet A, Robyn C, Huraux-Rendu C, et al. J Gynecol Obstet Biol Reprod (Paris). 1978;7:129–34. [Effect of ergot alkaloid derivatives on milk secretion in the immediate postpartum period] [PubMed: 641312]
CAS Registry Number
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- Drug class: antimigraine agents
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