Skip to Content

Enoxaparin Side Effects

In Summary

Commonly reported side effects of enoxaparin include: anemia and hemorrhage. Other side effects include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to enoxaparin: injectable, solution

Along with its needed effects, enoxaparin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enoxaparin:

More common Less common
  • Bruising
  • chest discomfort
  • collection of blood under the skin
  • confusion
  • continuing bleeding or oozing from the nose and/or mouth, or surgical wound
  • convulsions (seizures)
  • fever
  • irritability
  • lightheadedness
  • lower back pain
  • pain or burning while urinating
  • swelling of the hands or feet
  • tightness in the chest
  • uncontrolled bleeding at the site of injection
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
  • Back pain
  • burning, pricking, tickling, or tingling sensation
  • chest pain
  • chills
  • cough
  • decreased urine output
  • dilated neck veins
  • dizziness or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • fast or irregular heartbeat
  • general feeling of discomfort or illness
  • irregular breathing
  • leg weakness
  • problems with bowel or bladder function
  • skin rash or hives
  • sneezing
  • sore throat
  • sudden fainting
  • swelling of the face, fingers, feet, genitals, mouth, or tongue
  • thickening of the bronchial secretions
  • troubled breathing
  • weight gain
Incidence not known
  • Abdominal or stomach pain
  • deep, dark purple bruise
  • hives or welts
  • irregular heartbeat
  • itching, pain, redness, or swelling
  • large, flat, blue, or purplish patches in the skin
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • skin rash
  • unusual tiredness or weakness
  • weakness or heaviness of the legs

Some side effects of enoxaparin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Diarrhea
  • irritation, pain, or redness at the place of injection

For Healthcare Professionals

Applies to enoxaparin: injectable solution


The most common adverse reactions were bleeding, anemia, thrombocytopenia, elevation of serum aminotransferase, diarrhea, and nausea.[Ref]


Common (1% to 10%): Major hemorrhage
Uncommon (0.1% to 1%): Atrial fibrillation, heart failure
Frequency not reported: Hemorrhage
Postmarketing reports: Shock, valve thrombosis in patients with prosthetic heart valves[Ref]


Common (1% to 10%): Thrombocytopenia, anemia, platelet counts between 100,000 and 50,000/mm3
Uncommon (0.1% to 1%): Platelet counts less than 50,000/mm3
Frequency not reported: Thrombocytosis
Postmarketing reports: Hemorrhagic anemia, platelet count increased, eosinophilia[Ref]


Common (1% to 10%): ALT increased asymptomatically, AST increased asymptomatically
Frequency not reported: Hepatic enzymes increased
Postmarketing reports: Hepatocellular liver injury, cholestatic liver injury[Ref]


Common (1% to 10%): Nausea, diarrhea
Uncommon (0.1% to 1%): Retroperitoneal hemorrhage[Ref]


Common (1% to 10%): Injection site hematoma, injection site pain, other injection site reaction
Uncommon (0.1% to 1%): Local irritation, injection site skin necrosis
Postmarketing reports: Injection site nodules[Ref]


Common (1% to 10%): Urticaria, pruritus, erythema
Uncommon (0.1% to 1%): Bullous dermatitis
Postmarketing reports: Cutaneous vasculitis, skin necrosis, alopecia[Ref]


Common (1% to 10%): Peripheral edema, edema
Rare (less than 0.1%): Hyperkalemia
Postmarketing reports: Hyperlipidemia, hypertriglyceridemia[Ref]


Common (1% to 10%): Allergic reaction
Rare (0.01% to 0.1%): Anaphylactic/anaphylactoid reaction
Very rare (less than 0.01%): Immuno-allergic thrombocytopenia
Postmarketing reports: Immuno-allergic thrombocytopenia with thrombosis[Ref]


Common (1% to 10%): Dyspnea
Uncommon (0.1% to 1%): Lung edema, pneumonia[Ref]


Uncommon (0.1% to 1%): Hematuria[Ref]


Common (1% to 10%): Confusion[Ref]


Common (1% to 10%): Fever[Ref]

Nervous system

Uncommon (0.1% to 1%): Intracranial hemorrhage
Postmarketing reports: Headache, spinal hematoma[Ref]


Postmarketing reports: Osteoporosis following treatment longer than 3 months[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Lovenox (enoxaparin)." Rhone-Poulenc Rorer, Collegeville, PA.

Some side effects of enoxaparin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.