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Duobrii Side Effects

Generic name: halobetasol / tazarotene topical

Medically reviewed by Last updated on May 3, 2023.

Note: This document contains side effect information about halobetasol / tazarotene topical. Some dosage forms listed on this page may not apply to the brand name Duobrii.

Applies to halobetasol/tazarotene topical: topical application lotion.

Serious side effects of Duobrii

Along with its needed effects, halobetasol/tazarotene topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking halobetasol / tazarotene topical:

More common

Less common

Other side effects of Duobrii

Some side effects of halobetasol / tazarotene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to halobetasol / tazarotene topical: topical lotion.


Common (1% to 10%): Application site pain, folliculitis, skin atrophy, excoriation, rash, skin abrasion, skin exfoliation[Ref]


Postmarketing reports: Cataracts, glaucoma[Ref]


Common (1% to 10%): Contact dermatitis

Frequency not reported: Photosensitivity, sunburn[Ref]


Very common (10% or more): Hypothalamic-pituitary-adrenal (HPA) axis suppression (15%)[Ref]

Frequently asked questions


1. Product Information. Duobrii (halobetasol-tazarotene topical). Bausch Health US (formerly Valeant Pharmaceuticals). 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.