Skip to Content

Dofetilide Side Effects

In Summary

Commonly reported side effects of dofetilide include: ventricular arrhythmia, ventricular tachycardia, and chest pain. Other side effects include: flu-like symptoms. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dofetilide: oral capsule

Warning

Oral route (Capsule)

To minimize the risk of induced arrhythmia, patients initiated or re-initiated on dofetilide should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous ECG monitoring, and cardiac resuscitation.

Side effects requiring immediate medical attention

Along with its needed effects, dofetilide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dofetilide:

More common

Less common

  • Chest pain
  • confusion
  • facial or flaccid paralysis
  • numbness or tingling of the hands, feet, or face
  • paralysis
  • pounding, slow heartbeat
  • slurred speech
  • swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, or throat
  • troubled breathing
  • unexplained shortness of breath
  • unusual tiredness or weakness
  • weight gain
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of dofetilide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to dofetilide: oral capsule

General

The most frequent adverse events were headache, chest pain, and dizziness.[Ref]

Cardiovascular

Very common (10% or more): Ventricular arrhythmias (up to 14.5%), ventricular tachycardia (up to 12.4%)

Common (1% to 10%): Torsade de pointes, ventricular fibrillation, atrioventricular block, heart block

Uncommon (0.1% to 1%): Bundle branch block

Frequency not reported: Angina pectoris, atrial fibrillation, hypertension, palpitation, supraventricular tachycardia, bradycardia, heart arrest, myocardial infarct[Ref]

Nervous system

Very common (10% or more): Headache (11%)

Common (1% to 10%): Dizziness

Frequency not reported: Cerebral ischemia, cerebrovascular accident, facial paralysis, flaccid paralysis, migraine, paralysis, paresthesia, syncope[Ref]

Other

Very common (10% or more): Chest pain (10%)

Common (1% to 10%): Accidental injury, medical/surgical/health service procedure

Frequency not reported: Asthenia, pain, edema, peripheral edema, sudden death, application complication, injection complication, incision complication, insertion complication, device complication[Ref]

Respiratory

Common (1% to 10%): Respiratory tract infection, dyspnea, flu syndrome

Frequency not reported: Cough increased[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, abdominal pain[Ref]

Dermatologic

Common (1% to 10%): Rash

Frequency not reported: Sweating, angioedema[Ref]

Musculoskeletal

Common (1% to 10%): Back pain

Frequency not reported: Arthralgia[Ref]

Psychiatric

Common (1% to 10%): Insomnia

Frequency not reported: Anxiety[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Hepatic

Frequency not reported: Liver damage[Ref]

References

1. "Product Information. Tikosyn (dofetilide)" Pfizer US Pharmaceuticals, Atlanta, GA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.