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Dofetilide Side Effects

In Summary

Commonly reported side effects of dofetilide include: ventricular arrhythmia, ventricular tachycardia, and chest pain. Other side effects include: flu-like symptoms. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dofetilide: oral capsule

In addition to its needed effects, some unwanted effects may be caused by dofetilide. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dofetilide:

More common:
  • Dizziness
  • fainting
  • fast heartbeat
Less common:
  • Chest pain
  • confusion
  • facial or flaccid paralysis
  • numbness or tingling of the hands, feet, or face
  • paralysis
  • pounding, slow heartbeat
  • slurred speech
  • swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, or throat
  • troubled breathing
  • unexplained shortness of breath
  • unusual tiredness or weakness
  • weight gain
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with dofetilide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Abdominal or stomach pain
  • accidental injury
  • back pain
  • chills
  • cough
  • diarrhea
  • fever
  • flu-like symptoms
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • migraine
  • muscle aches and pains
  • nausea
  • rash
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • sweating
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to dofetilide: oral capsule

Cardiovascular

Torsade de pointes is the only arrhythmia reported by the manufacturer that showed a dose-response relationship.[Ref]

Cardiovascular effects have included ventricular arrhythmias, AV block, bundle branch block, heart block, chest pain, angioedema, bradycardia, cerebral ischemia, cerebrovascular accident, edema, heart arrest and myocardial infarct.[Ref]

General

General side effects including headache (11%), dizziness (8%), flu syndrome ( 4%), insomnia (4%), accidental injury (3%), back pain (3%) and rash (3%) and sudden death have been reported.[Ref]

Gastrointestinal

Gastrointestinal effects have included nausea (5%), diarrhea (3%) and abdominal pain (3%).[Ref]

Respiratory

Respiratory effects have included respiratory tract infection (7%), dyspnea (6%) and cough.[Ref]

Nervous system

Nervous system effects have included paresthesias, facial paralysis, paralysis, flaccid paralysis, migraine and syncope.[Ref]

Hepatic

Hepatic side effects including liver damage has been reported with a frequency of less than 2%.[Ref]

References

1. "Product Information. Tikosyn (dofetilide)" Pfizer US Pharmaceuticals, Atlanta, GA.

2. Frost L, Mortensen PE, Tingleff J, Platou ES, Christiansen EH, Christiansen N "Efficacy and safety of dofetilide, a new class III antiarrhythmic agent, in acute termination of atrial fibrillation or flutter afte coronary artery bypass surgery. Dofetilide Post-CABG Study Group." Int J Cardiol 58 (1997): 135-40

3. Lenz TL, Hilleman DE "Dofetilide, a new class III antiarrhythmic agent." Pharmacotherapy 20 (2000): 776-86

4. Crijns HJ, Kingma JH, Gosselink AT, Dalrymple HW, De Langen CD, Lie K "Sequential bilateral bundle branch block during dofetilide, a new class III antiarrhythmic agent, in a patient with atria fibrillation." J Cardiovasc Electrophysiol 4 (1993): 459-66

Not all side effects for dofetilide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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