Dipivefrin ophthalmic Side Effects
Applies to dipivefrin ophthalmic: ophthalmic solution
Ocular side effects have included injection (6.5%), stinging (6%), and burning (6%). Follicular conjunctivitis and mydriasis have been reported rarely. Corneal vascularization or vesicles, eyelid ectropion, papillary conjunctivitis, blepharoconjunctivitis, macular edema, corneal toxicity (dendritic keratitis, punctate keratitis, or epitheliopathy), and blurred vision have also been reported.
Ocular side effects associated with ocular administration of epinephrine have included conjunctival and corneal adrenochrome deposits.[Ref]
Some long-term studies have reported observations of follicular conjunctivitis in almost all patients with up to 40% classified as severe reactions.[Ref]
Cardiovascular side effects have included slight increases in heart rate and diastolic blood pressure.
Most placebo-controlled studies have reported mild average increases in heart rate (3 to 4 beats/min--with or without palpitations) or diastolic blood pressure (1 to 5 mm Hg) associated with dipivefrin.[Ref]
Hypersensitivity reactions have included bronchospasm associated with a formulation containing bisulfite preservative.[Ref]
Medically reviewed by Drugs.com. Last updated on Mar 9, 2021.
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10. Morrison JC, Robin AL "Adjunctive glaucoma therapy: a comparison of apraclonidine to dipivefrin when added to timolol maleate." Ophthalmology 96 (1989): 3-7
11. Bartley GB "Reversible lower eyelid ectropion associated with dipivefrin." Am J Ophthalmol 111 (1991): 650-1
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13. Schwartz HJ, Sher TH "Bisulfite intolerance manifest as bronchospasm following topical dipivefrin hydrochloride therapy for glaucoma." Arch Ophthalmol 103 (1985): 14-5
Some side effects may not be reported. You may report them to the FDA.