Dioval XX Side Effects
Generic name: estradiol
Medically reviewed by Drugs.com. Last updated on Jan 25, 2024.
Note: This document contains side effect information about estradiol. Some dosage forms listed on this page may not apply to the brand name Dioval XX.
For Healthcare Professionals
Applies to estradiol: compounding powder, intramuscular solution, oral tablet, transdermal emulsion, transdermal film extended release, transdermal gel, transdermal spray, vaginal ring.
Genitourinary
Very common (10% or more): Breast pain (29%)
Common (1% to 10%): Vulvovaginal pruritus, leukorrhea, vaginal hemorrhage, vaginal discharge, vaginal discomfort, menopause symptoms, breakthrough bleeding or spotting, dysmenorrhea, breast swelling, menorrhagia, metrorrhagia, endometrial hyperplasia
Uncommon (0.1% to 1%): Urinary problems
Rare (less than 0.1%): Galactorrhea
Postmarketing reports: Vaginal irritation, vaginal pain, genital pruritus, changes in bleeding pattern, pelvic pain, breast tenderness, vaginal ulceration, uterine fibroids[Ref]
Gastrointestinal
Very common (10% or more): Abdominal pain (16%),
Common (1% to 10%): Flatulence, nausea, diarrhea
Uncommon (0.1% to 1%): Vomiting
Postmarketing reports: Abdominal distension[Ref]
Musculoskeletal
Very common (10% or more): Back pain (11%), arthralgia (11%)
Common (1% to 10%): Leg cramps[Ref]
Cardiovascular
Common (1% to 10%): Varicose veins, cardiac symptoms (e.g. palpitations)
Uncommon (0.1% to 1%): Hot flush, hypertension, venous thromboembolic disease
Rare (less than 0.1%): Arterial hypertension
Postmarketing reports: Deep vein thrombosis, changes in blood pressure[Ref]
Nervous system
Very common (10% or more): Headache (18%)
Uncommon (0.1% to 1%): Vertigo, migraine
Rare (less than 0.1%): Aggravation of epilepsy
Postmarketing reports: Migraine aggravated, paresthesia, dizziness[Ref]
Oncologic
Uncommon (0.1% to 1%): Benign breast neoplasm, increased volume of uterine leiomyoma
Postmarketing reports: Endometrial cancer, breast cancer[Ref]
Other
Very common (10% or more): Pain (11%)
Common (1% to 10%): Edema
Uncommon (0.1% to 1%): Weight increased, asthenia
Postmarketing reports: Drug ineffectiveness, blood estrogen increase, fatigue, exacerbation of hereditary angioedema[Ref]
Psychiatric
Common (1% to 10%): Depression
Uncommon (0.1% to 1%): Sleep disorders, nervousness, mood swings
Rare (less than 0.1%): Change in libido
Postmarketing reports: Vaginismus, insomnia, anxiety, irritability[Ref]
Dermatologic
Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Rash
Rare (less than 0.1%): Skin discoloration, acne
Postmarketing reports: Urticaria, erythematous or pruritic rash, alopecia, hyperhidrosis, night sweats, contact dermatitis, eczema[Ref]
Ocular
Uncommon (0.1% to 1%): Vision abnormal NOS
Postmarketing reports: Visual disturbances, contact lens intolerance[Ref]
Hepatic
Rare (less than 0.1%): Liver function tests abnormalities
Postmarketing reports: Cholestatic jaundice[Ref]
Metabolic
Rare (less than 0.1%): Glucose intolerance
Postmarketing reports: Fluid retention[Ref]
Hypersensitivity
Rare (less than 0.1%): Anaphylactic reaction (with a past history of allergic reaction)
Postmarketing reports: Anaphylactic reactions, hypersensitivity[Ref]
Immunologic
Very common (10% or more): Upper respiratory tract infection (17%)
Common (1% to 10%): Vulvovaginal mycotic infection, pharyngitis, rhinitis, sinusitis, moniliasis genital
Uncommon (0.1% to 1%): Vaginitis/vaginal candidosis[Ref]
Local
Common (1% to 10%): Skin irritation (topical gel)
Postmarketing reports: Application site reaction[Ref]
More about Dioval XX (estradiol)
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- Side effects
- Dosage information
- During pregnancy
- Drug class: estrogens
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References
1. Auerbach R, Mittal K, Schwartz PE. Estrogen and progestin receptors in an ovarian ependymoma. Obstet Gynecol. 1988;71:1043-5.
2. Julian TM. Pseudoincontinence secondary to unopposed estrogen replacement in the surgically castrate premenopausal female. Obstet Gynecol. 1987;70:382-3.
3. Product Information. Climara (estradiol). Berlex Laboratories. 2001;PROD.
4. Product Information. Estrace (estradiol). Warner Chilcott Laboratories. 2001;PROD.
5. Nash HA, AlvarezSanchez F, Mishell DR, Fraser IS, Maruo T, Harmon TM. Estradiol-delivering vaginal rings for hormone replacement therapy. Am J Obstet Gynecol. 1999;181:1400-6.
6. Cerner Multum, Inc. Australian Product Information.
7. Product Information. Yuvafem (estradiol topical). AvKare Inc. 2017.
8. Product Information. Estradiol Vaginal Insert (estradiol topical). Teva Pharmaceuticals USA. 2017.
9. Boston Collaborative Drug Surveilance Program. Surgically confirmed gallbladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. N Engl J Med. 1974;290:15-9.
10. Crane MG, Harris JJ. Estrogens and hypertension: effect of discontinuing estrogens on blood pressure, exchangeable sodium, and the renin-aldosterone system. Am J Med Sci. 1978;276:33-55.
11. Crane MG, Harris JJ, Winsor W 3d. Hypertension, oral contraceptive agents, and conjugated estrogens. Ann Intern Med. 1971;74:13-21.
12. Rosenberg L, Slone D, Shapiro S, Kaufman D, Stolley PD, Miettinen OS. Noncontraceptive estrogens and myocardial infarction in young women. JAMA. 1980;244:339-42.
13. Jick H, Dinan B, Rothman KJ. Noncontraceptive estrogens and nonfatal myocardial infarction. JAMA. 1978;239:1407-8.
14. Wren BG, Routledge DA. Blood pressure changes: oestrogens in climacteric women. Med J Aust. 1981;2:528-31.
15. Belchetz PE. Hormonal treatment of postmenopausal women. N Engl J Med. 1994;330:1062-71.
16. Stampfer MJ, Colditz GA, Willett WC, et al. Postmenopausal estrogen and cardiovascular disease. Ten-year follow-up from the Nurses' Health Study. N Engl J Med. 1991;325:756-62.
17. Barrett-Connor E, Bush TL. Estrogen and coronary heart disease in women. JAMA. 1991;265:1861-7.
18. Grady D, Rubin SM, Petiti DB, et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. 1992;117:1016-36.
19. Barrett-Connor E, Wingard DL, Criqui MH. Postmenopausal estrogen use and heart disease risk factors in the 1980s. Rancho Bernardo, Calif, revisited. JAMA. 1989;261:1095-2100.
20. Schwartz J, Freeman R, Frishman W. Clinical pharmacology of estrogens: cardiovascular actions and cardioprotective benefits of replacement therapy in postmenopausal women. J Clin Pharmacol. 1995;35:1-16.
21. The Writing Group for the PEPI Trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA. 1995;273:199-208.
22. Collins P, Beale CM, Rosano GMC. Oestrogen as a calcium channel blocker. Eur Heart J. 1996;17 ( Suppl:27-31.
23. Bui MN, Arai AE, Hathaway L, Waclawiw MA, Csako G, Cannon RO 3rd. Effect of hormone replacement therapy on carotid arterial compliance in healthy postmenopausal women. Am J Cardiol. 2002;90:82-5.
24. Steiger MJ, Quinn NP. Hormone replacement therapy induced chorea. BMJ. 1991;302:762.
25. Cohen L, Coxwell WL, Melchione T, Koltun W, Gibson E, Gupta N, Roberts M. Low-dose 17-beta estradiol matrix transdermal system in the treatment of moderate-to-severe hot flushes in postmenopausal women. Curr Ther Res Clin Exp. 1999;60:534-47.
26. Obrink A, Bunne G, Collen J, Tjernberg B. Endometrial cancer and exogenous estrogens. Acta Obstet Gynecol Scand. 1979;58:123.
27. Palmer JR, Rosenberg L, Clarke EA, Miller DR, Shapiro S. Breast cancer risk after estrogen replacement therapy: results from the Toronto Breast Cancer Study. Am J Epidemiol. 1991;134:1386-95.
28. Kaufman DW, Palmer JR, de Mouzon J, Rosenberg L, Stolley PD, Warshauer ME, Zauber AG, Shapiro S. Estrogen replacement therapy and the risk of breast cancer: results from the case-control surveillance study. Am J Epidemiol. 1991;134:1375-85.
29. Spengler RF, Clarke EA, Woolever CA, Newman AM, Osborn RW. Exogenous estrogens and endometrial cancer: a case-control study and assessment of potential biases. Am J Epidemiol. 1981;114:497-506.
30. Thomas DB, Persing JP, Hutchinson WB. Exogenous estrogens and other risk factors for breast cancer in women with benign breast diseases. J Natl Cancer Inst. 1982;69:1017-25.
31. Antunes CM, Strolley PD, Rosenshein NB, Davies JL, Tonascia JA, Brown C, Burnett L, Rutledge A, Pokempner M, Garcia R. Endometrial cancer and estrogen use. Report of a large case-control study. N Engl J Med. 1979;300:9-13.
32. Gordon J, Reagan JW, Finkle WD, Ziel HK. Estrogen and endometrial carcinoma. An independent pathology review supporting original risk estimate. N Engl J Med. 1977;297:570-1.
33. Bergkvist L, Adami HO, Persson I, Hoover R, Schairer C. The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med. 1989;321:293-7.
34. Gray LA Sr, Christopherson WM, Hoover RN. Estrogens and endometrial carcinoma. Obstet Gynecol. 1977;49:385-9.
35. Colditz GA, Hankinson SE, Hunter DJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med. 1995;332:1589-93.
36. The Writing Group for the PEPI Trial. Effects of hormone replacement therapy on endometrial histology in postmenopausal women. JAMA. 1996;275:370-5.
37. Gapstur SM, Morrow M, Sellers TA. Hormone replacement therapy and risk of breast cancer with a favorable histology: results of the Iowa women's health study. JAMA. 1999;281:2091-7.
38. Oppenheim G. A case of rapid mood cycling with estrogen: implications for therapy. J Clin Psychiatry. 1984;45:34-5.
39. Conter RL, Longmire WP Jr. Recurrent hepatic hemangiomas. Possible association with estrogen therapy. Ann Surg. 1988;207:115-9.
40. Aldinger K, Ben-Menachem Y, Whalen G. Focal nodular hyperplasia of the liver associated with high-dosage estrogens. Arch Intern Med. 1977;137:357-9.
41. Molitch ME, Oill P, Odell WD. Massive hyperlipemia during estrogen therapy. JAMA. 1974;227:522-5.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.