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Dimenhydrinate Side Effects

For the Consumer

Applies to dimenhydrinate: oral solution, oral tablets, parenteral injection

Side effects include:

Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.

Paradoxical CNS stimulation in pediatric patients and occasionally in adults.

With IM injection: Pain at the injection site.

Because dimenhydrinate contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.

For Healthcare Professionals

Applies to dimenhydrinate: compounding powder, injectable solution, oral liquid, oral tablet, oral tablet chewable

General

The most frequently reported adverse reaction is drowsiness.[Ref]

Cardiovascular

Frequency not reported: Tachycardia[Ref]

Dermatologic

Frequency not reported: Skin rash[Ref]

Gastrointestinal

Frequency not reported: Dry mouth, epigastric distress, nausea[Ref]

Genitourinary

Frequency not reported: Difficult or painful urination[Ref]

Metabolic

Frequency not reported: Anorexia[Ref]

Nervous system

Frequency not reported: Drowsiness, dizziness, headache, excitation[Ref]

Ocular

Frequency not reported: Blurred vision[Ref]

Other

Frequency not reported: Lassitude[Ref]

Psychiatric

Frequency not reported: Nervousness, restlessness, insomnia[Ref]

Respiratory

Frequency not reported: Dry nose, dry throat, thickening of bronchial secretions[Ref]

References

1. "Product Information. Dramamine (dimenhydrinate)" Pharmacia and Upjohn, Kalamazoo, MI.

Some side effects of dimenhydrinate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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