Dimenhydrinate Dosage

Usual Adult Dose for Motion Sickness

-IM: 50 mg every 4 hours injected intramuscularly as needed; Maximum Dose: 100 mg every 4 hours

-IV: 50 mg every 4 hours injected intravenously over a period of 2 minutes; Maximum Dose: 100 mg every 4 hours

-Oral: 50 to 100 mg orally every 4 to 6 hours; Maximum Dose: 400 mg in 24 hours

Comments:
-For IV administration: Each mL (50 mg) must be diluted in 10 mL of 0.9% sodium chloride injection.
-The first dose should be taken one-half to one hour before starting activity.
-The injectable form is indicated when the oral form is impractical.

Use: Prevention and treatment of nausea, vomiting, dizziness, or vertigo associated with motion sickness.

Usual Pediatric Dose for Motion Sickness

IM: 1.25 mg/kg OR 37.5 mg/m2 injected intramuscularly 4 times a day; Maximum Dose: 300 mg/day

Oral:
-Age 2 to 5: 12.5 to 25 mg orally every 6 to 8 hours; Maximum Dose: 75 mg in 24 hours
-Age 6 to 11: 25 to 50 mg orally every 6 to 8 hours; Maximum Dose: 150 mg in 24 hours
-Age 12 and older: 50 to 100 mg orally every 4 to 6 hours; Maximum Dose: 400 mg in 24 hours

Comments:
-The first dose should be taken one-half to one hour before starting activity.
-The injectable form is indicated when the oral form is impractical.

Use: Prevention and treatment of nausea, vomiting, dizziness, or vertigo associated with motion sickness.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Do not use in patients younger than 2 years unless directed by a doctor.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:
-The solution form should not be injected intra-arterially.

Storage Requirements:
-This drug should be protected from moisture and stored at 20 to 25 degrees Celsius (68 to 77 Fahrenheit).

General:
-Overdosage: Convulsions, coma, respiratory depression, and drowsiness may occur with overdosage. There is no specific antidote; the manufacturer product information should be consulted for drugs that may be used to treat overdosage effects.
-In mice, the oral LD50 is 203 mg/kg and the intraperitoneal LD50 is 149 mg/kg; the LD50 in rats is 1,320 mg/kg.
-There is no human data indicating this drug is a carcinogen or mutagen.

Patient Advice:
-Avoid alcoholic drinks, sedatives, and tranquilizers while taking this drug.
-This drug may cause side effects such as drowsiness and dizziness that can affect your ability to perform certain activities; avoid driving and potentially hazardous activities such as operating machinery until you know how this drug affects you.
-If overdosage occurs, get immediate medical help or contact a Poison Control Center right away.