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Diclofenac ophthalmic Side Effects

In Summary

Commonly reported side effects of diclofenac ophthalmic include: increased intraocular pressure and keratitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to diclofenac ophthalmic: ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by diclofenac ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking diclofenac ophthalmic, check with your doctor or nurse immediately:

More common:
  • Eye redness, irritation, or pain
  • tearing of the eyes
Less common:
  • Blindness
  • blurred vision
  • burning, dry, or itching eyes
  • clear or yellow fluid from the eye
  • decreased vision or any change in vision
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • sensitivity to light
  • sticky or matted eyelashes
  • throbbing pain
Incidence not known:
  • Feeling of something in the eye

Minor Side Effects

Some of the side effects that can occur with diclofenac ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning and stinging of the eye
Less common:
  • Abdominal or stomach pain
  • chills
  • cold flu-like symptoms
  • cough or hoarseness
  • dizziness
  • fever
  • headache
  • lack or loss of strength
  • nausea
  • pain
  • runny nose
  • sleeplessness
  • sneezing
  • stuffy nose
  • swelling or puffiness of the face
  • trouble with sleeping
  • unable to sleep
  • vomiting

For Healthcare Professionals

Applies to diclofenac ophthalmic: ophthalmic solution


The most commonly reported side effects were lacrimation, keratitis, and transient burning/stinging.[Ref]


Very common (10% or more): Lacrimation (30%), keratitis (28%), transient burning/stinging (15%), elevated intraocular pressure (15%)
Common (1% to 10%): Abnormal vision, blurred vision, conjunctivitis, corneal deposits, corneal edema, corneal opacity, corneal lesions, eye discharge, eyelid swelling, eye pain, injection (redness), iritis, irritation, itching, ocular allergy
Uncommon (0.1% to 1%): Conjunctival follicules
Frequency not reported: Mydriasis, ocular hyperemia
Postmarketing reports: Corneal erosion, corneal infiltrates, corneal perforation, corneal thinning, corneal ulceration, epithelial breakdown[Ref]


Uncommon (0.1% to 1%): Hypersensitivity[Ref]


Frequency not reported: Abdominal pain, nausea, vomiting[Ref]

Nervous system

Frequency not reported: Dizziness, headache[Ref]


Frequency not reported: Urticaria, rash, eczema, erythema, pruritus[Ref]


Frequency not reported: Viral infection[Ref]


Uncommon (0.1% to 1%): Impaired healing
Frequency not reported: Asthenia, chills, facial edema, fever, pain[Ref]


Frequency not reported: Insomnia[Ref]


Rare (less than 0.1%): Dyspnea, exacerbation of asthma
Frequency not reported: Rhinitis, cough[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Voltaren (diclofenac)." Ciba Vision Ophthalmics, Duluth, GA.

Not all side effects for diclofenac ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.