Skip to Content

Dexilant SoluTab Side Effects

Generic Name: dexlansoprazole

Note: This document contains side effect information about dexlansoprazole. Some of the dosage forms listed on this page may not apply to the brand name Dexilant SoluTab.

For the Consumer

Applies to dexlansoprazole: oral capsule delayed release, oral tablet disintegrating delayed release

Along with its needed effects, dexlansoprazole (the active ingredient contained in Dexilant SoluTab) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dexlansoprazole:

Less common
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • continuing stomach pain
  • diarrhea
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • headache
  • incoherent speech
  • joint pain, stiffness, or swelling
  • lightheadedness, dizziness, or fainting
  • muscle pain, cramps, or weakness
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pain or discomfort in the arms, jaw, leg, back, or neck
  • pounding in the ears
  • rash or hives
  • shakiness in the legs, arms, hands, or feet
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unusual bleeding or bruising
  • vomiting of blood or material that looks like coffee grounds
  • watery or bloody diarrhea
Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chills
  • cough
  • drowsiness
  • muscle spasms (tetany) or twitching
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, or ankles
  • trembling
  • unusual weight gain

Some side effects of dexlansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abnormal dreams
  • body aches or pain
  • bloated or full feeling
  • burning or itching around the anus
  • change in taste or bad, unusual, or unpleasant (after) taste
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficult or painful urination
  • difficulty with moving
  • ear congestion
  • ear pain
  • excess air or gas in the stomach or intestines
  • falls
  • feeling of constant movement of self or surroundings
  • loss in sexual ability, desire, drive, or performance
  • loss of voice
  • metallic taste
  • muscle or bone pain
  • nasal congestion
  • passing gas
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sensation of spinning
  • sneezing
  • sore throat
  • sunburn
  • trouble sleeping

For Healthcare Professionals

Applies to dexlansoprazole: oral delayed release capsule


The most commonly reported adverse reactions included diarrhea, abdominal pain, and nausea.[Ref]


Frequency not reported: Angina, arrhythmia, bradycardia, chest pain, edema, myocardial infarction, palpitation, tachycardia, deep vein thrombosis, hot flush, hypertension[Ref]


Frequency not reported: Acne, dermatitis, erythema, pruritus, rash, skin lesion, urticaria
Postmarketing reports: Generalized rash, leukocytoclastic vasculitis[Ref]


Frequency not reported: Goiter, diabetes mellitus, hypothyroidism[Ref]


Common (1% to 10%): Diarrhea, abdominal pain, nausea, vomiting, flatulence
Frequency not reported: Abdominal discomfort, abdominal tenderness, abnormal feces, anal discomfort, Barrett's esophagus, bezoar, bowel sounds abnormal, breath odor, colitis microscopic, colonic polyp, constipation, dry mouth, duodenitis, dyspepsia, dysphagia, enteritis, eructation, esophagitis, gastric polyp, gastritis, gastroenteritis, gastrointestinal disorders, gastrointestinal hypermotility disorders, GERD, GI ulcers and perforation, hematemesis, hematochezia, hemorrhoids, impaired gastric emptying, irritable bowel syndrome, mucus stools, oral mucosal blistering, painful defecation, proctitis, paresthesia oral, rectal hemorrhage, retching, blood gastrin increased, rectal tenesmus, oropharyngeal pain
Postmarketing reports: Oral edema, pancreatitis, Clostridium difficile associated diarrhea[Ref]


Frequency not reported: Vulvo-vaginal infection, dysuria, micturition urgency, dysmenorrhea, dyspareunia, menorrhagia, menstrual disorder


Frequency not reported: Anemia, lymphadenopathy, mean corpuscular hemoglobin concentration (MCHC) decreased, neutropenia, increased neutrophils, platelet count decreased
Postmarketing reports: Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura[Ref]


Frequency not reported: Biliary colic, cholelithiasis, hepatomegaly, ALP increased, ALT increased, AST increased, bilirubin decreased/increased, liver function test abnormal
Postmarketing reports: Drug-induced hepatitis[Ref]


Frequency not reported: Hypersensitivity, anaphylaxis
Postmarketing reports: Anaphylactic shock (requiring emergency intervention), exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (some fatal)


Frequency not reported: Total protein increased, weight increased, appetite changes, hypercalcemia, hypokalemia, central obesity, cholecystitis acute, dehydration, hyperlipidemia, blood glucose increased, blood potassium increased, gout
Postmarketing reports: Hypomagnesemia, hyponatremia[Ref]


Frequency not reported: Fractures, joint sprains, arthralgia, arthritis, muscle cramps, musculoskeletal pain, myalgia, bursitis
Postmarketing reports: Bone fracture[Ref]

Nervous system

Frequency not reported: Altered taste, convulsion, dizziness, headaches, migraine, memory impairment, paresthesia, psychomotor hyperactivity, tremor, trigeminal neuralgia, restless legs syndrome, somnolence
Postmarketing reports: Cerebrovascular accident, transient ischemic attack[Ref]


Frequency not reported: Eye irritation, eye swelling
Postmarketing reports: Blurred vision[Ref]


Frequency not reported: B-cell lymphoma


Frequency not reported: Ear pain, tinnitus, vertigo, asthenia, chest pain, chills, feeling abnormal, inflammation, mucosal inflammation, nodule, pain, pyrexia, candida infections, viral infections, overdose, procedural pain, sunburn, falls, auditory hallucinations, folliculitis, herpes zoster, adverse drug reaction
Postmarketing reports: Facial edema, deafness[Ref]


Frequency not reported: Abnormal dreams, anxiety, depression, insomnia, libido changes[Ref]


Frequency not reported: Blood creatinine increased
Postmarketing reports: Acute renal failure[Ref]


Common (1% to 10%): Upper respiratory tract infection
Frequency not reported: Influenza, nasopharyngitis, oral herpes, pharyngitis, sinusitis, aspiration, asthma, bronchitis, cough, dysphonia, hiccups, hyperventilation, respiratory tract congestion, sore throat, epistaxis, tonsillitis, dyspnea
Postmarketing reports: Pharyngeal edema, throat tightness[Ref]


1. "Product Information. Kapidex (dexlansoprazole)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Some side effects of Dexilant SoluTab may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.