Depade Side Effects
Generic name: naltrexone
Medically reviewed by Drugs.com. Last updated on June 29, 2020.
Note: This document contains side effect information about naltrexone. Some of the dosage forms listed on this page may not apply to the brand name Depade.
For the Consumer
Applies to naltrexone: oral tablet
Other dosage forms:
Side effects requiring immediate medical attention
Along with its needed effects, naltrexone (the active ingredient contained in Depade) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking naltrexone:
- Abdominal or stomach pain (severe)
- blurred vision, aching, burning, or swollen eyes
- chest pain
- discomfort while urinating or frequent urination
- hallucinations or seeing, hearing, or feeling things that are not there
- mental depression or other mood or mental changes
- ringing or buzzing in the ears
- shortness of breath
- swelling of the face, feet, or lower legs
- weight gain
Side effects not requiring immediate medical attention
Some side effects of naltrexone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abdominal or stomach cramping or pain (mild or moderate)
- anxiety, nervousness, restlessness or trouble sleeping
- joint or muscle pain
- nausea or vomiting
- unusual tiredness
- cough, hoarseness, runny or stuffy nose, sinus problems, sneezing, or sore throat
- fast or pounding heartbeat
- increased thirst
- loss of appetite
- sexual problems in males
For Healthcare Professionals
Applies to naltrexone: compounding powder, intramuscular powder for injection extended release, oral tablet
Very common (10% or more): Headache (25%), dizziness/syncope (13%)
Common (1% to 10%): Somnolence/sedation
Very common (10% or more): Insomnia/sleep disorder (14%), anxiety (12%)
Common (1% to 10%): Depression
Uncommon (0.1% to 1%): Suicide attempt/ideation
Very common (10% or more): Nausea (33%), vomiting NOS (14%), diarrhea (13%), abdominal pain (11%)
Common (1% to 10%): Dry mouth, toothache
Very common (10% or more): Alanine aminotransferase increased (13%), aspartate aminotransferase increased (10%)
Common (1% to 10%): Gamma-glutamyltransferase increased
Very common (10% or more): Injection site tenderness (45%), injection site induration (35%), injection site pain (17%), other injection site reaction (primarily nodules, swelling) (15%), injection site pruritus (10%)
Common (1% to 10%): Injection site ecchymosis[Ref]
Very common (10% or more): Arthralgia/arthritis/joint stiffness (12%)
Common (1% to 10%): Back pain/stiffness, muscle cramps
Frequency not reported: Chills, joint stiffness, muscle spasms, myalgia, pain in limb[Ref]
Very common (10% or more): Asthenic conditions (23%)
Frequency not reported: Angina pectoris, angina unstable, atrial fibrillation, cardiac failure congestive, coronary artery atherosclerosis, myocardial infarction, palpitations, deep vein thrombosis[Ref]
Common (1% to 10%): Rash
Very common (10% or more): Anorexia/appetite decreased NOS/appetite disorder NOS (14%)
Very common (10% or more): Abnormal creatinine phosphokinase levels (17%)[Ref]
Frequency not reported: Eosinophil counts increased, decreased platelet count[Ref]
Very common (10% or more): Pharyngitis (11%)
Common (1% to 10%): Nasopharyngitis
1. "Product Information. Vivitrol (naltrexone)." Alkermes, Inc, Cambridge, MA.
2. "Product Information. Naltrexone Hydrochloride (naltrexone)." Accord Biopharma Inc, Durham, NC.
Frequently asked questions
- What happens if you drink alcohol while taking naltrexone?
- Can you drink alcohol on Vivitrol or will you get sick?
- Does naltrexone cause weight gain?
- Should I take naltrexone in the morning or at night?
- What to avoid when taking naltrexone?
- How long does naltrexone take to work?
- How long does Vivitrol last in your system?
- What's the difference between naltrexone and naloxone?
- How does naltrexone make you feel?
- What happens if you take opiates while on Vivitrol?
- Does this drug make you sleepy?
- Is naltrexone a controlled substance?
- Does this drug block endorphins?
More about Depade (naltrexone)
- During Pregnancy or Breastfeeding
- Dosage Information
- Imprints, Shape & Color Data
- Drug Interactions
- Drug class: antidotes
Related treatment guides
Some side effects may not be reported. You may report them to the FDA.