D-Hist D Side Effects
Generic name: dexchlorpheniramine / methscopolamine / pseudoephedrine
Note: This document contains side effect information about dexchlorpheniramine / methscopolamine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name D-Hist D.
Do not take dexchlorpheniramine, methscopolamine, and pseudoephedrine if you have used a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
Drinking alcohol can increase certain side effects of dexchlorpheniramine, methschopolamine, and pseudoephedrine.
Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by methscopolamine.
Ask a doctor or pharmacist before using any other cold or allergy medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.
Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.
Do not take dexchlorpheniramine, methscopolamine, and pseudoephedrine for longer than 7 days in a row. If your symptoms do not improve, or if they get worse and you also have a fever, talk to your doctor.
Get emergency medical help if you have any of these signs of an allergic reaction while taking dexchlorpheniramine / methscopolamine / pseudoephedrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
fast or irregular heart rate;
feeling like you might pass out;
rash or flushing; or
Less serious side effects of dexchlorpheniramine / methscopolamine / pseudoephedrine may include:
dryness of your eyes, nose, and mouth;
weakness or nervousness;
nausea, bloating, heartburn, or constipation;
changes in taste;
decreased sweating; or
feeling restless or excited (especially in children).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to dexchlorpheniramine / methscopolamine / pseudoephedrine: oral tablet extended release.
Nervous system side effects have included nervousness, insomnia, restlessness, headache, irritability, fear, anxiety, tenseness, tremor, weakness, hallucinations, convulsions, central nervous system depression, drowsiness, and dizziness.[Ref]
Ocular side effects have included blurred vision.[Ref]
Respiratory side effects have included respiratory difficulty and excessive dryness of the nose.[Ref]
Genitourinary side effects have included dysuria and urinary retention in patients with prostatic hypertrophy.[Ref]
Gastrointestinal side effects have included gastric irritation and excessive dryness of the mouth and throat.[Ref]
More about D-Hist D (dexchlorpheniramine / methscopolamine / pseudoephedrine)
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
1. Product Information. Durahist D (dexchlorpheniramine/methscopolamine/PSE). Kowa Pharmaceuticals America (formerly ProEthic). 2022.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.