Covera-HS Side Effects
Generic Name: verapamil
Note: This document contains side effect information about verapamil. Some of the dosage forms listed on this page may not apply to the brand name Covera-HS.
For the Consumer
Applies to verapamil: oral capsule extended release, oral capsule extended release 24 hr, oral tablet, oral tablet extended release, oral tablet extended release 24 hr
Other dosage forms:
Along with its needed effects, verapamil (the active ingredient contained in Covera-HS) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking verapamil:Less common
- Blue lips and fingernails
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain
- coughing that sometimes produces a pink frothy sputum
- difficult, fast, noisy breathing, sometimes with wheezing
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
- increased sweating
- lightheadedness, dizziness, or fainting
- pale skin
- shortness of breath
- slow or irregular heartbeat
- sore throat
- swelling in legs and ankles
- unusual tiredness or weakness
- cold sweats
- feeling of warmth
- redness of the face, neck, arms and occasionally, upper chest
Some side effects of verapamil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Difficulty having a bowel movement (stool)
- Acid or sour stomach
- difficulty in moving
- joint pain
- muscle aching or cramping
- muscle pains or stiffness
- stomach discomfort, upset, or pain
- trouble sleeping
- unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
- swollen joints
For Healthcare Professionals
Applies to verapamil: compounding powder, intravenous solution, oral capsule extended release, oral tablet, oral tablet extended release
Very common (10% or more): Headache (up to 12.1%)
Common (1% to 10%): Dizziness, lethargy
Rare (0.01% to 0.1%): Seizures
Frequency not reported: Rotary nystagmus, sleepiness, vertigo, lightheadedness, tingling, numbness, neuropathy
Postmarketing reports: Syncope, cerebrovascular accident, equilibrium disorders, parkinsonism/extrapyramidal symptoms/syndrome, paresthesia, shakiness/tremor, paralysis/tetraparesis, somnolence[Ref]
Cardiovascular side effects may occur with greater intensity at higher doses or in patients with a history of myocardial damage.
Approximately 15% of patients who had atrial flutter/fibrillation and received this drug and digoxin developed resting ventricular rates below 50 beats/min; in the same trial, asymptomatic hypotension occurred in approximately 5% of patients.
Asystole occurred after second/third degree AV block and was usually short in duration, with spontaneous cardiac action returning within seconds in the form of a sinus rhythm.[Ref]
Common (1% to 10%): Symptomatic hypotension/hypotension/abrupt blood pressure fall, sinus bradycardia/bradycardia (heart rate less than 50 beats/minute), severe tachycardia, ankle edema/edema, development/aggravation of congestive heart failure (CHF), atrioventricular (AV) block, peripheral edema
Uncommon (0.1% to 1%): Second-/third-degree AV block, palpitations, orthostasis
Postmarketing reports: Angina pectoris/chest pain, AV dissociation, ECG abnormal, claudication, hypertension, myocardial infarction, sinus arrest with asystole, decreased myocardial contractility, cardiogenic shock, bradyarrhythmia in atrial fibrillation, vasculitis, erythromelalgia[Ref]
Non-obstructive paralytic ileus was reversible when treatment was stopped.
Gingival hyperplasia occurred when this drug was given over a prolonged period of time, and was reversible once the drug was discontinued.[Ref]
Common (1% to 10%): Constipation, dyspepsia, nausea, diarrhea, flatulence
Uncommon (0.1% to 1%): Abdominal discomfort/pain
Frequency not reported: Non-obstructive paralytic ileus/ileus, bloating
Postmarketing reports: Dry mouth, gastrointestinal stress, gingival hyperplasia, vomiting[Ref]
Bronchospasm and laryngeal spasm occurred during hypersensitivity reactions.[Ref]
Common (1% to 10%): Scalp irritation, rash
Uncommon (0.1% to 1%): Itching, urticaria, flushing, exanthema
Frequency not reported: Diaphoresis, photodermatitis
Postmarketing reports: Ecchymosis, bruising, alopecia/hair loss, hyperkeratosis, macules, Stevens-Johnson syndrome, hyperhidrosis/sweating, erythema multiforme, Quincke's edema/angioneurotic edema[Ref]
Itch and urticaria occurred in hypersensitivity reactions.[Ref]
Common (1% to 10%): Myalgia
Frequency not reported: Muscle fatigue
Postmarketing reports: Muscle cramps, arthralgia[Ref]
Reversible elevations liver enzymes occurred during treatment, and are likely the result of a hypersensitivity reaction (e.g., allergic hepatitis).[Ref]
Postmarketing reports: Renal failure[Ref]
Gynecomastia occurred in older male patients on prolonged treatment, and was reversible upon discontinuation of this drug.[Ref]
Postmarketing reports: Gynecomastia[Ref]
Postmarketing reports: Purpura[Ref]
Postmarketing reports: Blurred vision[Ref]
1. "Product Information. Verelan PM (verapamil)." Schwarz Pharma, Mequon, WI.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
4. "Product Information. Covera-HS (verapamil)." Searle, Skokie, IL.
5. "Product Information. Calan (verapamil)." Searle, Skokie, IL.
6. "Product Information. Isoptin (verapamil)." Knoll Pharmaceutical Company, Whippany, NJ.
Some side effects of Covera-HS may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about Covera-HS (verapamil)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- 1 Review – Add your own review/rating
- Drug class: calcium channel blocking agents
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.