Codeine / phenylephrine / triprolidine Side Effects
For the Consumer
Applies to codeine / phenylephrine / triprolidine: oral syrup
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Chest pain or pressure or a fast heartbeat.
- Trouble breathing, slow breathing, or shallow breathing.
- Noisy breathing.
- Feeling very sleepy.
- Feeling confused.
- A heartbeat that does not feel normal.
- Hallucinations (seeing or hearing things that are not there).
- Mood changes.
- Very bad belly pain.
- Very bad headache.
- Trouble passing urine.
- Change in eyesight.
- Very upset stomach or throwing up.
- Very hard stools (constipation).
- Feeling very tired or weak.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling nervous and excitable.
- Not able to sleep.
- Feeling sleepy.
- Hard stools (constipation).
- Upset stomach or throwing up.
- Sweating a lot.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to codeine / phenylephrine / triprolidine: oral liquid
The most commonly occurring side effects include dry mouth, dizziness, sleepiness, and disturbed coordination.[Ref]
Frequency not reported: Hypotension, palpitations, tachycardia, extrasystoles
Frequency not reported: Dry mouth, dry throat, epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation
Frequency not reported: Urinary frequency, difficult urination, urinary retention
Frequency not reported: Confusion, restlessness, excitation, anxiety, nervousness, irritability, insomnia, euphoria, hysteria, hallucination
Frequency not reported: Blurred vision, diplopia
Frequency not reported: Chills, fatigue, vertigo, tinnitus
Frequency not reported: Drug rash, photosensitivity, excessive perspiration, urticaria
Frequency not reported: Sedation, sleepiness, dizziness, disturbed coordination, tremor, paresthesias, neuritis, convulsions, CNS depression
Frequency not reported: Nasal dryness, thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness, respiratory depression
1. "American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults." J Am Geriatr Soc 63 (2015): 2227-46
2. "Product Information. Histex-AC (codeine / phenylephrine / triprolidine)." Allegis Pharmaceuticals, Canton, MS.
Some side effects of codeine / phenylephrine / triprolidine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
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- Drug class: upper respiratory combinations
Other brands: Histex-AC
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