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Clindex Side Effects

Generic Name: chlordiazepoxide / clidinium

Note: This document contains side effect information about chlordiazepoxide / clidinium. Some of the dosage forms listed on this page may not apply to the brand name Clindex.

For the Consumer

Applies to chlordiazepoxide / clidinium: oral capsule

Along with its needed effects, chlordiazepoxide/clidinium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlordiazepoxide / clidinium:

Incidence not known
  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • dark urine
  • difficulty with speaking
  • dizziness
  • drooling
  • drowsiness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching or rash
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful or difficult urination
  • pale skin
  • restlessness
  • shakiness and unsteady walk
  • shuffling walk
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • swelling
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking chlordiazepoxide / clidinium:

Symptoms of overdose
  • Blurred vision
  • change in consciousness
  • difficulty having a bowel movement (stool)
  • dry mouth
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Some side effects of chlordiazepoxide / clidinium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Inability to have or keep an erection
  • increase or loss in sexual ability, desire, drive, or performance
  • increased or decreased interest in sexual intercourse
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide / clidinium: oral capsule


The most common adverse events were sedation, dizziness, somnolence, ataxia, fatigue, and balance disorder.[Ref]

Nervous system

Frequency not reported: Sedation, dizziness, somnolence, ataxia, balance disorder, drowsiness, syncope, extrapyramidal symptoms[Ref]

The elderly and debilitated may be more susceptible to the side effects of chlordiazepoxide-clidinium. Drowsiness, ataxia, and confusion have occasionally been reported at the lower dosage ranges.[Ref]


Rare (less than 0.1%): Gastrointestinal disorder, constipation
Frequency not reported: Nausea, dry mouth[Ref]


Rare (less than 0.1%): Bone marrow depression (e.g. thrombocytopenia, leukopenia, agranulocytosis, pancytopenia)[Ref]


Frequency not reported: Jaundice, blood bilirubin increased, transaminases increase, hepatic dysfunction[Ref]


Common (1% to 10%): Fatigue
Frequency not reported: Blood alkaline phosphatase increased, asthenia, edema, changes in EEG patterns (low-voltage fast activity)[Ref]


Uncommon (0.1% to 1%): Lacrimation decreased, accommodation disorders
Rare (less than 0.1%): Visual impairment including diplopia

Frequency not reported: Blurring of vision[Ref]


Rare (less than 0.1%): Urinary retention, erectile dysfunction, menstrual disorder
Frequency not reported: Minor menstrual irregularities, urinary hesitancy[Ref]


Rare (less than 0.1%): Skin reaction (e.g. rash, pruritus)
Frequency not reported: Skin eruptions[Ref]


Frequency not reported: Hypersensitivity[Ref]


Frequency not reported: Muscular weakness[Ref]


Uncommon (0.1% to 1%): Increased appetite[Ref]


Rare (less than 0.1%): Libido disorder
Frequency not reported: Amnesia, hallucinations, dependence, depression, restlessness, agitation, irritability, depressed level of consciousness, aggression, delusion, nightmares, psychotic disorder, abnormal behavior, emotional disturbances, paradoxical drug reaction (e.g. anxiety, sleep disorders, insomnia, suicide attempt, suicidal ideation), confusion[Ref]


Frequency not reported: Respiratory depression, increased viscosity of bronchial secretion[Ref]


Rare (less than 0.1%): Hypotension
Frequency not reported: Tachycardia, palpitations[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Librax (chlordiazepoxide-clidinium)." Valeant Pharmaceuticals, Costa Mesa, CA.

Some side effects of Clindex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.