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Clindex Side Effects

Generic Name: chlordiazepoxide / clidinium

Note: This page contains information about the side effects of chlordiazepoxide / clidinium. Some of the dosage forms included on this document may not apply to the brand name Clindex.

For the Consumer

Applies to chlordiazepoxide / clidinium: oral capsule

In addition to its needed effects, some unwanted effects may be caused by chlordiazepoxide / clidinium. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking chlordiazepoxide / clidinium:

Incidence not known:
  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • dark urine
  • difficulty with speaking
  • dizziness
  • drooling
  • drowsiness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • itching or rash
  • loss of appetite
  • loss of balance control
  • lower back or side pain
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful or difficult urination
  • pale skin
  • restlessness
  • shakiness and unsteady walk
  • shuffling walk
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiffness of the limbs
  • swelling
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bruising or bleeding
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking chlordiazepoxide / clidinium, get emergency help immediately:

Symptoms of overdose:
  • Blurred vision
  • change in consciousness
  • difficulty having a bowel movement (stool)
  • dry mouth
  • lack of coordination
  • loss of consciousness
  • sleepiness or unusual drowsiness

Minor Side Effects

Some of the side effects that can occur with chlordiazepoxide / clidinium may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Inability to have or keep an erection
  • increase or loss in sexual ability, desire, drive, or performance
  • increased or decreased interest in sexual intercourse
  • menstrual changes
  • skin blisters

For Healthcare Professionals

Applies to chlordiazepoxide / clidinium: oral capsule

Nervous system

The elderly and debilitated may be more susceptible to the side effects of chlordiazepoxide-clidinium. Drowsiness, ataxia, and confusion have occasionally been reported at the lower dosage ranges.[Ref]

Nervous system side effects have included drowsiness, ataxia, confusion, and extrapyramidal symptoms. Chlordiazepoxide-clidinium may impair the psychomotor skills necessary for driving. Changes in electroencephalogram (EEG) patterns (low-voltage fast activity) have been reported during and after chlordiazepoxide treatment.[Ref]


Gastrointestinal side effects have included nausea, constipation, and dryness of the mouth.[Ref]


Hematologic side effects have included blood dyscrasias (including agranulocytosis).[Ref]


Hepatic side effects have included jaundice and hepatic dysfunction.[Ref]


Other side effects have included increased and decreased libido, edema, and withdrawal symptoms. Rarely, syncope has been reported.[Ref]

Withdrawal symptoms after abrupt cessation of chlordiazepoxide-clidinium may include dysphoria, insomnia, convulsions, tremor, abdominal and muscle cramps, vomiting, sweating, agitation, restlessness, and anxiety.[Ref]


Ocular side effects have included blurring of vision.[Ref]


Genitourinary side effects have included minor menstrual irregularities and urinary hesitancy.[Ref]


Dermatologic side effects have included skin eruptions.[Ref]


1. "Product Information. Librax (chlordiazepoxide-clidinium)." Valeant Pharmaceuticals, Costa Mesa, CA.

Not all side effects for Clindex may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.