Clindex Side Effects

Generic name: chlordiazepoxide / clidinium

Medically reviewed by Drugs.com. Last updated on Jul 3, 2024.

Note: This document provides detailed information about Clindex Side Effects associated with chlordiazepoxide / clidinium. Some dosage forms listed on this page may not apply specifically to the brand name Clindex.

Applies to chlordiazepoxide / clidinium: oral capsule.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Warning: Risks From Concomitant Use With Opioids; Abuse, Misuse, and Addiction; and Dependence and Withdrawal Reactions. Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.

Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate.

Limit dosages and durations to the minimum required.

Follow patients for signs and symptoms of respiratory depression and sedation.The use of benzodiazepines, include chlordiazepoxide hydrochloride, a component of Librax®, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.

Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes.

Before prescribing chlordiazepoxide hydrochloride/clidinium bromide and throughout treatment, assess each patient's risk for abuse, misuse, and addiction.The continued use of benzodiazepines, including chlordiazepoxide hydrochloride/clidinium bromide, may lead to clinically significant physical dependence.

The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose.

Abrupt discontinuation or rapid dosage reduction of chlordiazepoxide hydrochloride/clidinium bromide after continued use may precipitate acute withdrawal reactions, which can be life-threatening.

To reduce the risks of withdrawal reactions, use a gradual taper to discontinue chlordiazepoxide hydrochloride/clidinium bromide or reduce the dosage.

Serious side effects of Clindex

Along with its needed effects, chlordiazepoxide / clidinium may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlordiazepoxide / clidinium:

Incidence not known

• chills
• clay-colored stools
• confusion
• cough or hoarseness
• dark urine
• difficulty with speaking
• dizziness
• drooling
• drowsiness
• fever with or without chills
• general feeling of tiredness or weakness
• headache
• itching or rash
• loss of appetite
• loss of balance control
• lower back or side pain
• muscle trembling, jerking, or stiffness
• nausea
• painful or difficult urination
• pale skin
• restlessness
• shakiness and unsteady walk
• shuffling walk
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• stiffness of the limbs
• stomach pain
• swelling
• twisting movements of the body
• uncontrolled movements, especially of the face, neck, and back
• unpleasant breath odor
• unsteadiness, trembling, or other problems with muscle control or coordination
• unusual bruising or bleeding
• unusual tiredness or weakness
• vomiting of blood
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking chlordiazepoxide / clidinium:

Symptoms of overdose

• agitation
• blurred vision
• change in consciousness
• changes in patterns and rhythms of speech
• confusion
• difficulty having a bowel movement (stool)
• dry mouth
• lack of coordination
• loss of consciousness
• loss of strength or energy
• nightmares
• shakiness and unsteady walk
• sleepiness or unusual drowsiness
• slurred speech
• talkativeness
• trouble speaking
• unsteadiness, trembling, or other problems with muscle control or coordination
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• unusual excitement, nervousness, restlessness, or irritability
• unusual paleness

Other side effects of Clindex

Some side effects of chlordiazepoxide / clidinium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• inability to have or keep an erection
• increase or loss in sexual ability, desire, drive, or performance
• increased or decreased interest in sexual intercourse
• menstrual changes
• skin blisters

For healthcare professionals

Applies to chlordiazepoxide / clidinium: oral capsule.

General adverse events

The most commonly reported side effects included anticholinergic effects (e.g., blurred vision, constipation, dry mouth, urinary hesitancy).^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Decreased libido, increased libido
• Rare (0.01% to 0.1%): Confusion^[Ref]

The elderly and debilitated may be more susceptible to confusion; this side effect has occasionally been reported at the lower dosage ranges.^[Ref]

Gastrointestinal

• Uncommon (0.1% to 1%): Constipation, nausea
• Frequency not reported: Dry mouth^[Ref]

Constipation most commonly occurred when patients took spasmolytic agents concurrently and/or with a low residue diet.^[Ref]

Hepatic

• Uncommon (0.1% to 1%): Jaundice, liver dysfunction^[Ref]

Hematologic

• Uncommon (0.1% to 1%): Agranulocytosis, blood dyscrasias^[Ref]

Nervous system

• Uncommon (0.1% to 1%): Extrapyramidal symptoms
• Rare (0.01% to 0.1%): Drowsiness
• Very rare (less than 0.01%): Syncope
• Frequency not reported: Anticholinergic effects, changes in EEG patterns (low-voltage fast activity)^[Ref]

The elderly and debilitated may be more susceptible to drowsiness and syncope; the side effects have occasionally been reported at the lower dosage ranges.^[Ref]

Genitourinary

• Uncommon (0.1% to 1%): Minor menstrual irregularities
• Frequency not reported: Urinary hesitancy^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Edema^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Skin eruptions^[Ref]

Other

• Rare (0.01% to 0.1%): Ataxia^[Ref]

The elderly and debilitated may be more susceptible to ataxia; this side effect has occasionally been reported at the lower dosage ranges.^[Ref]

Ocular

• Frequency not reported: Blurred vision^[Ref]

Further information

Clindex side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer