Clenpiq Side Effects
Generic name: citric acid/magnesium oxide/sodium picosulfate
Medically reviewed by Drugs.com. Last updated on Sep 17, 2022.
Note: This document contains side effect information about citric acid/magnesium oxide/sodium picosulfate. Some dosage forms listed on this page may not apply to the brand name Clenpiq.
Applies to citric acid/magnesium oxide/sodium picosulfate: oral solution.
Serious side effects of Clenpiq
Along with its needed effects, citric acid/magnesium oxide/sodium picosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking citric acid/magnesium oxide/sodium picosulfate:
Incidence not known
- Bleeding of the rectum
- bloody stools
- decreased urine output
- dizziness or fainting
- dry mouth
- fast, slow, or irregular heartbeat
- hives, itching, skin rash
- increased thirst
- jerking or shaking of the muscles
- joint pain, stiffness, or swelling
- loss of bowel control
- loss of consciousness
- muscle pain or cramps
- numbness or tingling in the hands, feet, or lips
- pinpoint red or purple spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- stomach pain and tenderness
- swelling of the eyelids, face, lips, ankles, hands, or feet
- tightness in the chest
- troubled breathing or swallowing
- unusual tiredness or weakness
Other side effects of Clenpiq
Some side effects of citric acid/magnesium oxide/sodium picosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Pain in the rectum
For Healthcare Professionals
Applies to citric acid/magnesium oxide/sodium picosulfate: oral powder for reconstitution, oral solution.
The most commonly reported side effects included headache, nausea, vomiting, and proctalgia.[Ref]
Very common (10% or more): Low glomerular filtration rate (up to 28.5%)
Common (1% to 10%): High creatinine[Ref]
Very common (10% or more): Orthostatic changes (up to 20%)
Uncommon (0.1% to 1%): Orthostatic hypotension
Frequency not reported: Cardiac arrhythmias[Ref]
Orthostatic changes included changes in blood pressure and heart rate.
In a study, approximately 20% of pediatric patients 9 to 16 years of age given this drug had orthostatic changes for up to 5 days compared to 7% of patients given the comparator drug regimen (polyethylene glycol and electrolytes solution plus bisacodyl).[Ref]
Very common (10% or more): Hypermagnesemia (up to 11.6%)
Uncommon (0.1% to 1%): Hypocalcemia
Hypermagnesemia occurred in 11.6% of patients using the split-dose regimen compared to 8.7% of patients using the day-before regimen the day of the colonoscopy.
Abnormally low glucose levels were reported in asymptomatic pediatric patients, with one occurring at the colonoscopy, and one at the 5-day follow-up visit.
Hyponatremia has occurred with/without convulsions.[Ref]
Uncommon (0.1% to 1%): Abdominal cramps, anal irritation, aphthoid ileal ulcers/mild reversible aphthoid ileal ulcers, diarrhea, ileal ulcers. fecal incontinence
Rare (0.01% to 0.1%): Anal incontinence
Postmarketing reports: Severe diarrhea[Ref]
Since abdominal bloating, distention, pain/cramping, and watery diarrhea were predicted to occur as part of the colon cleansing regimen, these side effects were included only if patients required medical attention or the condition significantly worsened during the study and was not in the frame of the usual clinical course.[Ref]
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Convulsions, decreased/loss of consciousness, dizziness, epilepsy, generalized tonic-clonic seizures, grand mal convulsion, seizures, syncope
Rare (0.01% to 0.1%): Presyncope[Ref]
Common (1% to 10%): Sleep disorder
Uncommon (0.1% to 1%): Confusional state, disorientation
Frequency not reported: Sleep disturbance[Ref]
Common (1% to 10%): Fatigue
Frequency not reported: Pain[Ref]
Uncommon (0.1% to 1%): Erythematous rash, maculopapular rash, purpura, rash, urticaria
Uncommon (0.1% to 1%): Anaphylactic reaction, hypersensitivity
Frequency not reported: Aspiration
Frequently asked questions
More about Clenpiq (citric acid/magnesium oxide/sodium picosulfate)
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- During pregnancy
- FDA approval history
- Drug class: laxatives
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Related treatment guides
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate)." Ferring Pharmaceuticals Inc (2022):
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.