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Clenpiq Dosage

Generic name: SODIUM PICOSULFATE 10mg in 160mL, MAGNESIUM OXIDE 3.5g in 160mL, ANHYDROUS CITRIC ACID 12g in 160mL
Dosage form: solution

Medically reviewed on October 3, 2018.

Important Administration Instructions

  • Correct fluid and electrolyte abnormalities before administration of CLENPIQ.
  • CLENPIQ is ready to drink. It is a clear solution with possible presence of visible particles and it does not need to be diluted prior to administration. One bottle of CLENPIQ is equivalent to one dose.
  • Two doses of CLENPIQ are required for a complete preparation for colonoscopy either as a Split-Dose (preferred) or Day-Before dosing regimen.
  • The preferred method is the "Split-Dose" method and consists of two separate doses: the first dose during the evening before the colonoscopy and the second dose the next day, during the morning prior to the colonoscopy [see Dosage and Administration (2.2)].
  • The alternative method is the "Day-Before" method and consists of two separate doses: the first dose during the afternoon or early evening before the colonoscopy and the second dose 6 hours later during the evening before the colonoscopy [see Dosage and Administration (2.3)].
  • Additional fluids must be consumed after every dose of CLENPIQ in both dosing regimens [see Dosage and Administration (2.2) and Warnings and Precautions (5.1)].
  • Consume only clear fluids (no solid food) from the start of CLENPIQ treatment until after the colonoscopy.
  • Do not eat solid food or dairy and do not drink anything colored red or purple.
  • Do not drink alcohol.
  • Do not take other laxatives while taking CLENPIQ
  • Do not take oral medications within one hour of starting CLENPIQ.
  • If taking tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, or penicillamine, take these medications at least 2 hours before and not less than 6 hours after administration of CLENPIQ.
  • Stop consumption of all fluids at least 2 hours before the colonoscopy.

Split-Dose Dosage Regimen (Preferred Method)

The Split-Dose regimen is the preferred dosing method. Instruct patients to take two separate doses in conjunction with fluids, as follows:

Dose 1 – On the day before colonoscopy:

  • Instruct patients to consume only clear liquids (no solid food or dairy) on the day before the colonoscopy up until 2 hours before the time of the colonoscopy.
  • Take the first dose (1 bottle) of CLENPIQ during the evening before the colonoscopy (e.g., 5:00 to 9:00 PM).
  • Follow CLENPIQ by drinking five 8-ounce cups (cup provided) of clear liquids (40 ounces total) within 5 hours and before bed.
  • If severe bloating, distention, or abdominal pain occurs, following the first dose, delay the second dose until the symptoms resolve.

Dose 2 – Next morning on the day of colonoscopy (start approximately 5 hours prior to colonoscopy):

  • Continue to consume only clear liquids (no solid food or dairy).
  • Take the second dose (the second bottle) of CLENPIQ.
  • Following the CLENPIQ dose, drink at least three 8-ounce cups (cup provided) of clear liquids (24 ounces) at least 2 hours before the colonoscopy.

Day-Before Dosage Regimen (Alternative Method)

The Day-Before regimen is the alternative dosing method for patients for whom the Split-Dosing is inappropriate. Instruct patients to take two separate doses in conjunction with fluids, as follows:

Dose 1 – On the day before colonoscopy:

  • Instruct patients to consume only clear liquids (no solid food or dairy) on the day before the colonoscopy up until 2 hours before the time of the colonoscopy.
  • Take the first dose (1 bottle) of CLENPIQ in the afternoon or early evening before the colonoscopy (e.g., 4:00 to 6:00 PM).
  • Following the CLENPIQ dose, drink five 8-ounce cups (cup provided) of clear liquids (40 ounces total) within 5 hours and before the next dose.
  • If severe bloating, distention, or abdominal pain occurs, following the first dose, delay the second dose until the symptoms resolve.

Dose 2 – Approximately 6 hours later in the evening the night before the colonoscopy (e.g., 10:00 PM to 12:00 AM):

  • Take the second dose (the second bottle) of CLENPIQ.
  • Following the CLENPIQ dose, drink three 8-ounce cups (cup provided) (24 ounces) of clear liquids within 5 hours and before bed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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