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Clenpiq Dosage

Generic name: SODIUM PICOSULFATE 10mg in 175mL, MAGNESIUM OXIDE 3.5g in 175mL, ANHYDROUS CITRIC ACID 12g in 175mL
Dosage form: oral solution
Drug class: Laxatives

Medically reviewed by Drugs.com. Last updated on Jan 4, 2023.

Important Administration Instructions

  • Correct fluid and electrolyte abnormalities before administration of CLENPIQ.
  • CLENPIQ is ready to drink. It is a clear solution with possible presence of visible particles and it does not need to be diluted prior to administration. One bottle of CLENPIQ is equivalent to one dose.
  • Two doses of CLENPIQ are required for a complete preparation for colonoscopy as a Split-Dose regimen.
  • The Split-Dose method consists of two separate doses: the first dose during the evening before the colonoscopy and the second dose the next day, during the morning prior to the colonoscopy [see Dosage and Administration (2.2)].
  • Additional liquids must be consumed after every dose of CLENPIQ: five or more 8-ounce cups of clear liquids after the first dose and four or more 8-ounce cups of clear liquids after the second dose [see Dosage and Administration (2.2), Warnings and Precautions (5.1)].
  • Consume only clear liquids (no solid food) from the start of CLENPIQ treatment until after the colonoscopy.
  • Do not eat solid food or dairy and do not drink anything colored red or purple.
  • Do not drink alcohol.
  • Do not take other laxatives while taking CLENPIQ.
  • Do not take oral medications within one hour of starting CLENPIQ.
  • If taking tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, or penicillamine, take these medications at least 2 hours before and not less than 6 hours after administration of CLENPIQ.
  • Stop consumption of all liquids at least 2 hours before the colonoscopy.

Split-Dose Dosage Regimen

The recommended dosage in adults and pediatric patients 9 years of age and older is shown below. Instruct patients to take two separate doses in conjunction with liquids, as follows:

Dose 1 – On the day before colonoscopy:

  • Instruct patients to consume only clear liquids (no solid food or dairy) on the day before the colonoscopy up until 2 hours before the time of the colonoscopy.
  • Take the first dose (1 bottle) of CLENPIQ during the evening before the colonoscopy (e.g., 5:00 PM to 9:00 PM).
  • Follow CLENPIQ by drinking five or more 8-ounce cups (cup provided) of clear liquids within 5 hours and before bed.
  • If severe bloating, distention, or abdominal pain occurs, following the first dose, delay the second dose until the symptoms resolve.

Dose 2 – Next morning on the day of colonoscopy (start approximately 5 hours prior to colonoscopy):

  • Continue to consume only clear liquids (no solid food or dairy).
  • Take the second dose (the second bottle) of CLENPIQ.
  • Following the CLENPIQ dose, drink four or more 8-ounce cups (cup provided) of clear liquids up to 2 hours before the colonoscopy.

Frequently asked questions

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