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Clavulanate / ticarcillin Side Effects

For the Consumer

Applies to clavulanate / ticarcillin: intravenous powder for solution, intravenous solution

Along with its needed effects, clavulanate / ticarcillin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking clavulanate / ticarcillin:

  • Blood in the urine
  • frequent urination
  • lower abdominal or stomach cramping
  • painful urination
Incidence not known
  • Abdominal or stomach cramps, pain, or tenderness
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • changes in skin color
  • chest pain or discomfort
  • chills
  • clay-colored stools
  • convulsions
  • cough
  • dark urine
  • diarrhea
  • diarrhea, watery and severe, which may also be bloody
  • dizziness
  • fast heartbeat
  • fever
  • general tiredness and weakness
  • headache
  • increased thirst
  • irritability
  • itching
  • joint or muscle pain
  • loss of appetite
  • lower back or side pain
  • muscle twitching
  • nausea or vomiting
  • pain, tenderness, or swelling of the foot or leg
  • pinpoint red spots on the skin
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • restlessness
  • seizures
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling or inflammation of the mouth
  • swollen glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • upper right abdominal or stomach pain
  • vomiting of blood
  • yellow eyes or skin

Some side effects of clavulanate / ticarcillin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • change in taste or bad unusual or unpleasant (after) taste
  • difficulty with moving
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • muscle aching, cramping, or stiffness
  • passing gas
  • swollen joints

For Healthcare Professionals

Applies to clavulanate / ticarcillin: intravenous powder for injection, intravenous solution


The risk of significant bleeding may be increased in patients over the age of 60 years, patients receiving cytotoxic chemotherapy, patients with preexisting thrombocytopenia, and azotemia, and patients undergoing surgical procedures.

Leukopenia has been reported in 23% of patients with liver disease receiving beta-lactam antibiotics.[Ref]

Common (1% to 10%): Elevated eosinophils, thrombocytosis
Very rare (less than 0.01%): Hemolytic anemia
Frequency not reported: Bleeding manifestations, immune hemolytic anemia, positive Coombs test
Postmarketing reports: Thrombocytopenia, leukopenia, neutropenia, eosinophilia, decreased hemoglobin or hematocrit, prolonged prothrombin time and bleeding time[Ref]


Common (1% to 10%): Elevated AST, elevated ALT
Postmarketing reports: Elevated AST, elevated ALT, elevated serum bilirubin, transient hepatitis, cholestatic jaundice[Ref]


Common (1% to 10%): Nausea, diarrhea
Frequency not reported: Clostridium difficile-associated diarrhea
Postmarketing reports: Stomatitis, flatulence, nausea, vomiting and diarrhea, epigastric pain, pseudomembranous colitis[Ref]

Onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy.[Ref]


Common (1% to 10%): Rash
Postmarketing reports: Skin rash, pruritus, urticaria, bullous reactions (including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome)[Ref]


Common (1% to 10%): Injection site phlebitis
Frequency not reported: Injection site erythema, injection site infiltration
Postmarketing reports: Injection site pain, injection site burning, injection site swelling, injection site induration, thrombophlebitis with IV administration[Ref]

Nervous system

Postmarketing reports: Headache, giddiness, neuromuscular hyperirritability, convulsive seizures, taste and smell disturbances[Ref]

Convulsions have been reported rarely, particularly in patients with renal dysfunction or those using high doses.[Ref]


Postmarketing reports: Hypersensitivity reactions (including skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, bronchospasm, wheezing, anaphylactic reactions, bullous reactions [including erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome])[Ref]


Postmarketing reports: Elevated serum creatinine and/or BUN[Ref]


Postmarketing reports: Arthralgia, myalgia


Postmarketing reports: Drug fever, chills, chest discomfort, decreased serum potassium


Postmarketing reports: Bronchospasm, wheezing


Frequency not reported: Hypokalemia
Postmarketing reports: Elevated serum alkaline phosphatase, elevated serum LDH, hypernatremia, decreased uric acid[Ref]

Some studies have shown a correlation between the degree of hypokalemia and the dose of ticarcillin in addition to the serum BUN/creatinine ratio. These findings suggest that dehydration and high doses may be risk factors for hypokalemia.[Ref]


Frequency not reported: Vaginal yeast infections
Postmarketing reports: Hemorrhagic cystitis[Ref]

An increased incidence of vaginal yeast infections has been associated with penicillins.[Ref]


Frequency not reported: Hallucinations


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2. Fass RJ, Copelan EA, Brandt JT, Moeschberger ML, Ashton JJ "Platelet-mediated bleeding caused by broad-spectrum penicillins." J Infect Dis 155 (1987): 1242-8

3. Tehan S, Horobin J, Gordonsmith R, McLatchie GR "Ticarcillin plus clavulanic acid (timentin): further UK trial results." Br J Clin Pract 42 (1988): 8-16

4. Sanders CV, Marier RL, Aldridge KE, Derks FW, Martin DH "Safety and effectiveness of ticarcillin plus clavulanic acid in the treatment of community-acquired acute pyelonephritis in adult women." Am J Med 79 (1985): 96-100

5. "Product Information. Timentin (ticarcillin-clavulanate)." SmithKline Beecham, Philadelphia, PA.

6. Mostow SR, O'Brien RF "Safety and effectiveness of ticarcillin plus clavulanate potassium in treatment of lower respiratory tract infections." Am J Med 79 (1985): 78-80

7. Croydon EA, Hermoso C "An evaluation of the safety and tolerance to timentin." J Antimicrob Chemother 17 (1986): 233-40

8. Gentry LO, Macko V, Lind R, Heilman A "Ticarcillin plus clavulanic acid (timentin) therapy for osteomyelitis." Am J Med 79 (1985): 116-21

9. Stuart JJ "Ticarcillin-induced hemorrhage in a patient with thrombocytosis." South Med J 73 (1980): 1084-5

10. Link AS, Jr "Efficacy and safety of ticarcillin plus clavulanic acid and piperacillin in patients with lower respiratory tract infections." Am J Med 79 (1985): 86-7

11. Gastineau D, Spector R, Philips D "Severe neutropenia associated with ticarcillin therapy." Ann Intern Med 94 (1981): 711-2

12. Schwigon CD, Hulla FW, Schulza B, Maslak A "Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units." J Antimicrob Chemother 17 (1986): 115-22

13. Ryan J, Dudley FJ "Cholestasis with ticarcillin-potassium clavulanate (timentin)." Med J Aust 156 (1992): 291

14. Sweet JM, Jones MP "Intrahepatic cholestasis due to ticarcillin-clavulanate." Am J Gastroenterol 90 (1995): 675-6

15. Westenfelder M, Pelz K, Hulla FW "Clinical evaluation of timentin in complicated urinary tract infections." J Antimicrob Chemother 17 (1986): 97-102

16. Shenep JL, Hughes WT, Roberson PK, et al "Vancomycin, ticarcillin, and amikacin compared with ticarcillin-clavulanate and amikacin in the empirical treatment of febrile, neutropenic children with cancer." N Engl J Med 319 (1988): 1053-8

17. Ramakrishnan K, Scheid DC "Diagnosis and management of acute pyelonephritis in adults." Am Fam Physician 71 (2005): 933-42

18. Brown LA, Goldberg ND, Shearer WT "Long-term ticarcillin desensitization by the continuous oral administration of penicillin." J Allergy Clin Immunol 69 (1982): 51-4

19. Ramirez-Ronda CH, Gutierrez J, Bermudez RH "Comparative effectiveness, safety and tolerance of mezlocillin and ticarcillin: a prospective randomized trial." J Antimicrob Chemother 9 (1982): 125-9

20. Finch RA "Hypernatremia during lithium and ticarcillin therapy." South Med J 74 (1981): 376-7

21. Welter J, Wittman DH, Freitag V "Ticarcillin therapy of risk patients with infections due to pseudomonas aeruginosa." J Int Med Res 9 (1981): 44-51

22. Nanji AA, Lindsay J "Ticarcillin associated hypokalemia." Clin Biochem 15 (1982): 118-9

Some side effects of clavulanate / ticarcillin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.