Cinvanti Side Effects

Generic name: aprepitant

Medically reviewed by Drugs.com. Last updated on Sep 27, 2024.

Note: This document provides detailed information about Cinvanti Side Effects associated with aprepitant. Some dosage forms listed on this page may not apply specifically to the brand name Cinvanti.

Applies to aprepitant: intravenous emulsion.

Other dosage forms:

• oral capsule, oral powder for suspension

Serious side effects of Cinvanti

Along with its needed effects, aprepitant (the active ingredient contained in Cinvanti) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aprepitant:

More common side effects

• blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• sweating
• unusual tiredness or weakness

Rare side effects

• bloody, black, or tarry stools
• burning feeling while urinating
• chest pain or discomfort
• chills
• cough
• defects in intelligence, short-term memory, learning ability, and attention
• difficult or painful urination
• fast, irregular, pounding, or racing heartbeat or pulse
• fever
• frequent urination
• general feeling of discomfort or illness
• heartburn
• increased sensitivity of the skin to sunlight
• increased volume of pale, dilute urine
• indigestion
• lightheadedness, dizziness, or fainting
• lower back or side pain
• pale skin
• redness or other discoloration of the skin
• severe and continuing nausea
• severe stomach pain, cramping, burning
• severe sunburn
• slow heartbeat
• sore throat
• swelling
• tender, swollen glands in the neck
• trouble breathing
• trouble walking
• trouble breathing
• ulcers, sores, or white spots in the mouth
• unusual bleeding or bruising
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• vomiting
• vomiting of material that looks like coffee grounds

Incidence not known

• blistering, peeling, or loosening of the skin
• chest tightness
• diarrhea
• difficulty swallowing
• hives, itching, skin rash
• joint or muscle pain
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red skin lesions, often with a purple center
• red, irritated eyes
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• unusual tiredness or weakness

Other side effects of Cinvanti

Some side effects of aprepitant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• constipation

Rare side effects

• abnormal dreams
• acne
• anxiety
• body aches or pain
• burning, dry, or itching eyes
• change or loss in taste
• confusion about identity, place, and time
• congestion
• continuing ringing or buzzing or other unexplained noise in the ears
• discharge, excessive tearing
• dry throat
• false or unusual sense of well-being
• feeling of warmth
• hearing loss
• hoarseness
• increased sweating
• increased thirst
• muscle cramp or weakness
• oily skin
• redness of the face, neck, arms and occasionally, upper chest
• redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
• runny nose
• sleepiness or unusual drowsiness
• sneezing
• stomach discomfort
• voice changes
• weight gain

For healthcare professionals

Applies to aprepitant: intravenous emulsion, oral capsule, oral powder for reconstitution.

General adverse events

The most commonly reported side effects included headache, fatigue, neutropenia, constipation, and pruritus.^[Ref]

Other

• Very common (10% or more): Fatigue (up to 15%)
• Common (1% to 10%): Asthenia, extremity pain, pyrexia
• Uncommon (0.1% to 1%): Malaise
• Rare (0.01% to 0.1%): Tinnitus
• Frequency not reported: Hypothermia, pain^[Ref]

Hematologic

• Very common (10% or more): Neutropenia (up to 13%)
• Common (1% to 10%): Anemia, hemoglobin decreased, leukopenia, white blood cell count decreased
• Uncommon (0.1% to 1%): Febrile neutropenia, thrombocytopenia
• Rare (0.01% to 0.1%): Neutrophil count decreased
• Frequency not reported: Blood albumin decreased^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 13%)
• Common (1% to 10%): Abdominal pain, constipation, dyspepsia, eructation, flatulence, nausea, vomiting
• Uncommon (0.1% to 1%): Dry mouth, gastritis, gastroesophageal reflux disease, oral candidiasis
• Rare (0.01% to 0.1%): Abdominal distention, duodenal ulcer perforation, feces hard, neutropenic colitis, stomatitis
• Frequency not reported: Abdominal pain upper, acid reflux, bowel sounds abnormal, epigastric discomfort, obstipation, stomach discomfort, subileus^[Ref]

Local

• Common (1% to 10%): Infusion-site erythema, infusion-site induration, infusion-site pain, infusion-site pruritus, infusion-site thrombophlebitis
• Uncommon (0.1% to 1%): injection-site pain, vessel puncture-site pain^[Ref]

Cardiovascular

• Common (1% to 10%): Bradycardia, flushing, hypertension, hypotension
• Uncommon (0.1% to 1%): Edema peripheral, flushing, hot flush, palpitations
• Rare (0.01% to 0.1%): Cardiovascular disorder, chest discomfort, edema
• Frequency not reported: Blood pressure decreased, hematoma, operative hemorrhage^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache, peripheral neuropathy
• Uncommon (0.1% to 1%): Dysgeusia, somnolence
• Rare (0.01% to 0.1%): Cognitive disorder, gait disturbance, lethargy
• Frequency not reported: Hypoesthesia, sensory disturbance, syncope
• Postmarketing reports: Ifosfamide-induced neurotoxicity^[Ref]

Hepatic

• Common (1% to 10%): ALT increased, AST increased
• Uncommon (0.1% to 1%): Blood alkaline phosphatase increased
• Frequency not reported: Blood bilirubin increased/bilirubin increased^[Ref]

Respiratory

• Common (1% to 10%): Cough, hiccups
• Uncommon (0.1% to 1%): Dyspnea, oropharyngeal pain, pharyngitis
• Rare (0.01% to 0.1%): Postnasal drip, sneezing, throat irritation
• Frequency not reported: Hypoxia, respiratory depression, wheezing^[Ref]

Metabolic

• Common (1% to 10%): Decreased appetite, dehydration
• Uncommon (0.1% to 1%): Blood potassium decreased/hypokalemia
• Rare (0.01% to 0.1%): Blood sodium decreased/hyponatremia, polydipsia, weight decreased
• Frequency not reported: Blood glucose increased/hyperglycemia, hypovolemia, thirst, weight gain^[Ref]

Dermatologic

• Common (1% to 10%): Pruritus
• Uncommon (0.1% to 1%): Acne, alopecia, hyperhidrosis, rash
• Rare (0.01% to 0.1%): Photosensitivity reaction, rash pruritic, seborrhea, skin lesion, Stevens-Johnson syndrome, toxic epidermal necrolysis
• Frequency not reported: Oily skin, urticaria^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia
• Uncommon (0.1% to 1%): Anxiety
• Rare (0.01% to 0.1%): Abnormal behavior, agitation, behavior changes, disorientation, euphoria/euphoric mood
• Frequency not reported: Dream abnormality^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection
• Uncommon (0.1% to 1%): Dysuria, proteinuria
• Rare (0.01% to 0.1%): Pollakiuria, red blood cells urine positive, urine output increased
• Frequency not reported: Microscopic hematuria, polyuria^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Musculoskeletal pain
• Rare (0.01% to 0.1%): Muscular weakness, muscle spasms
• Frequency not reported: Dysarthria, muscle cramp, myalgia^[Ref]

Renal

• Uncommon (0.1% to 1%): Blood urea increased
• Rare (0.01% to 0.1%): Glucose urine present^[Ref]

Immunologic

• Rare (0.01% to 0.1%): Candidiasis, staphylococcal infection
• Frequency not reported: Postoperative infection, wound dehiscence^[Ref]

Ocular

• Rare (0.01% to 0.1%): Conjunctivitis
• Frequency not reported: Miosis, visual acuity reduced^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylactic reactions, angioedema, hypersensitivity reactions
• Postmarketing reports: Anaphylactic shock, anaphylaxis^[Ref]

Frequently asked questions

• What is the difference between Cinvanti and Emend?

Further information

Cinvanti side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer