Skip to Content

Ciloxan Side Effects

Generic Name: ciprofloxacin ophthalmic

Note: This page contains information about the side effects of ciprofloxacin ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Ciloxan.

In Summary

Common side effects of Ciloxan include: corneal deposits. Other side effects include: eye discomfort. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ciprofloxacin ophthalmic: ophthalmic ointment, ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by ciprofloxacin ophthalmic (the active ingredient contained in Ciloxan). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking ciprofloxacin ophthalmic, check with your doctor or nurse as soon as possible:

  • Allergic reaction, such as skin rash, hives, or itching
  • blurred vision or other change in vision
  • eye pain
  • irritation (severe) or redness of eye
  • nausea

Minor Side Effects

Some of the side effects that can occur with ciprofloxacin ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning or other discomfort of eye
  • crusting or crystals in corner of eye
Less common:
  • Bad taste following use in the eye
  • feeling of something in eye
  • itching of eye
  • redness of the lining of the eyelids
  • Dryness of eye
  • increased sensitivity of eyes to light
  • swelling of eyelid
  • tearing of eye

For Healthcare Professionals

Applies to ciprofloxacin ophthalmic: ophthalmic ointment, ophthalmic solution


The most common side effects were ocular discomfort, local burning/discomfort, dysgeusia, corneal deposits, and white crystalline precipitates.[Ref]


White topical ocular precipitates have been observed in patients with corneal ulcer and frequent dosing of this drug which resolved after continued application of this drug. Precipitate did not preclude continued use of this drug and did not adversely affect the clinical course of recovery. Onset was within 1 to 7 days after starting therapy and resolution varied from immediately to 13 days after starting therapy.[Ref]

Very common (10% or more): White crystalline precipitates (medication residue; up to 17%)
Common (1% to 10%): Corneal deposits, ocular discomfort, ocular hyperemia/erythema/redness, local burning/discomfort, eyelid margin crusting, crystals/scales, foreign body sensation, itching, conjunctival hyperemia, keratopathy
Uncommon (0.1% to 1%): Punctate keratitis, eyelid edema, lacrimation increased/tearing, photophobia, corneal infiltrates, decreased visual acuity/decreased vision, blurred vision, dry eye, eye pain, eye swelling, eye pruritus, eye discharge, eyelid exfoliation, conjunctival edema, erythema of eyelid/lid margin hyperemia, corneal staining, chemosis, eye inflammation, corneal toxicity, allergy, intolerance, heavy sensation, conjunctival reaction, eye hypoesthesia/numbing sensation, conjunctivitis, punctate epithelial erosion, progression of infiltrate
Rare (0.01% to 0.1%): Ocular toxicity, keratitis/keratoconjunctivitis, corneal disorder, corneal epithelium defect, diplopia, asthenopia, eye irritation, hordeolum
Frequency not reported: Epitheliopathy[Ref]

Nervous system

Common (1% to 10%): Dysgeusia/bad taste after instillation
Uncommon (0.1% to 1%): Headache
Rare (0.01% to 0.1%): Dizziness/lightheadedness[Ref]


Uncommon (0.1% to 1%): Nausea
Rare (0.01% to 0.1%): Diarrhea, abdominal pain[Ref]


Uncommon (0.1% to 1%): Paranasal sinus hypersecretion/sinus drainage
Rare (0.01% to 0.1%): Rhinitis


Rare (0.01% to 0.1%): Hypersensitivity/allergic reactions

Systemic quinolones:
-Frequency not reported: Hypersensitivity (anaphylactic) reactions[Ref]

Serious and occasionally fatal hypersensitivity (anaphylactic) reactions (some after first dose) have been reported with systemic quinolones.[Ref]


Rare (0.01% to 0.1%): Dermatitis

Systemic ciprofloxacin:
-Uncommon (0.1% to 1%): Phototoxicity

Locally-applied fluoroquinolones:
-Very rare (less than 0.01%): Generalized rash, toxic epidermolysis, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria[Ref]

Moderate to severe phototoxicity has been reported in some patients exposed to direct sunlight while using oral ciprofloxacin.[Ref]


Rare (0.01% to 0.1%): Ear pain, drug intolerance, abnormal laboratory test


Ruptures of the shoulder, hand, Achilles, or other tendons (requiring surgical repair or resulting in prolonged disability) have been reported with systemic fluoroquinolones. Risk of such ruptures may be increased in patients using concomitant corticosteroids, especially geriatric patients and in tendons under high stress (including the Achilles tendon).

Postmarketing reports: Tendon disorder

Systemic fluoroquinolones:
-Frequency not reported: Tendon ruptures


Frequency not reported: Acute psychosis (visual and auditory hallucinations, irrational speech, behavioral disturbances)[Ref]

At least 1 case of acute psychosis (visual and auditory hallucinations, irrational speech, and behavioral disturbances) has been reported after ocular administration. The symptoms resolved upon discontinuation.[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ciloxan (ciprofloxacin ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

4. Wilhelmus KR, Abshire RL "Corneal ciprofloxacin precipitation during bacterial keratitis." Am J Ophthalmol 136 (2003): 1032-7

5. Tripathi A, Chen SI, O'Sullivan S "Clinicopathologic reports, case reports, and small case series: acute psychosis following the use of topical ciprofloxacin." Arch Ophthalmol 120 (2002): 669-70

Not all side effects for Ciloxan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.