Ciloxan Side Effects
Generic name: ciprofloxacin ophthalmic
Medically reviewed by Drugs.com. Last updated on Mar 30, 2024.
Note: This document provides detailed information about Ciloxan Side Effects associated with ciprofloxacin ophthalmic. Some dosage forms listed on this page may not apply specifically to the brand name Ciloxan.
Applies to ciprofloxacin ophthalmic: ophthalmic ointment, ophthalmic solution.
Precautions
If your or your child's eye infection does not improve within a few days, or if it becomes worse, check with your doctor.
This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you or your child have a rash, itching, red or swollen skin around the eye or eyelid, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
This medicine may cause your eyes to become more sensitive to light than they are normally. Wearing sunglasses and avoiding too much exposure to bright light may help lessen the discomfort.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Common side effects of Ciloxan
Some side effects of ciprofloxacin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- burning or other discomfort of the eye
- crusting or crystals in corner of the eye
Less common side effects
- bad taste following use in the eye
- feeling of something in the eye
- itching of the eye
- redness of the lining of the eyelids
Rare side effects
- difficulty seeing at night
- dryness of the eye
- increased sensitivity of the eyes to light
- swelling of the eyelid
- tearing of the eye
Serious side effects of Ciloxan
Along with its needed effects, ciprofloxacin ophthalmic (the active ingredient contained in Ciloxan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ciprofloxacin ophthalmic:
Rare side effects
- blurred vision or other change in vision
- eye pain
- irritation (severe) or redness of the eye
- nausea
- skin rash, hives, or itching
For healthcare professionals
Applies to ciprofloxacin ophthalmic: ophthalmic ointment, ophthalmic solution.
General adverse events
The most common side effects were ocular discomfort, local burning/discomfort, dysgeusia, corneal deposits, and white crystalline precipitates.[Ref]
Ocular
- Very common (10% or more): White crystalline precipitates (medication residue; up to 17%)
- Common (1% to 10%): Corneal deposits, ocular discomfort, ocular hyperemia/erythema/redness, local burning/discomfort, eyelid margin crusting, crystals/scales, foreign body sensation, itching, conjunctival hyperemia, keratopathy
- Uncommon (0.1% to 1%): Punctate keratitis, eyelid edema, lacrimation increased/tearing, photophobia, corneal infiltrates, decreased visual acuity/decreased vision, blurred vision, dry eye, eye pain, eye swelling, eye pruritus, eye discharge, eyelid exfoliation, conjunctival edema, erythema of eyelid/lid margin hyperemia, corneal staining, chemosis, eye inflammation, corneal toxicity, allergy, intolerance, heavy sensation, conjunctival reaction, eye hypoesthesia/numbing sensation, conjunctivitis, punctate epithelial erosion, progression of infiltrate
- Rare (0.01% to 0.1%): Ocular toxicity, keratitis/keratoconjunctivitis, corneal disorder, corneal epithelium defect, diplopia, asthenopia, eye irritation, hordeolum
- Frequency not reported: Epitheliopathy[Ref]
White topical ocular precipitates have been observed in patients with corneal ulcer and frequent dosing of this drug which resolved after continued application of this drug. Precipitate did not preclude continued use of this drug and did not adversely affect the clinical course of recovery. Onset was within 1 to 7 days after starting therapy and resolution varied from immediately to 13 days after starting therapy.[Ref]
Nervous system
- Common (1% to 10%): Dysgeusia/bad taste after instillation
- Uncommon (0.1% to 1%): Headache
- Rare (0.01% to 0.1%): Dizziness/lightheadedness[Ref]
Gastrointestinal
Respiratory
- Uncommon (0.1% to 1%): Paranasal sinus hypersecretion/sinus drainage
- Rare (0.01% to 0.1%): Rhinitis
Hypersensitivity
- Rare (0.01% to 0.1%): Hypersensitivity/allergic reactions
Systemic quinolones:
- Frequency not reported: Hypersensitivity (anaphylactic) reactions[Ref]
Serious and occasionally fatal hypersensitivity (anaphylactic) reactions (some after first dose) have been reported with systemic quinolones.[Ref]
Dermatologic
- Rare (0.01% to 0.1%): Dermatitis
Systemic ciprofloxacin:
- Uncommon (0.1% to 1%): Phototoxicity
Locally-applied fluoroquinolones:
- Very rare (less than 0.01%): Generalized rash, toxic epidermolysis, exfoliative dermatitis, Stevens-Johnson syndrome, urticaria[Ref]
Moderate to severe phototoxicity has been reported in some patients exposed to direct sunlight while using oral ciprofloxacin.[Ref]
Other
- Rare (0.01% to 0.1%): Ear pain, drug intolerance, abnormal laboratory test
Musculoskeletal
- Postmarketing reports: Tendon disorder
Systemic fluoroquinolones:
- Frequency not reported: Tendon ruptures
Ruptures of the shoulder, hand, Achilles, or other tendons (requiring surgical repair or resulting in prolonged disability) have been reported with systemic fluoroquinolones. Risk of such ruptures may be increased in patients using concomitant corticosteroids, especially geriatric patients and in tendons under high stress (including the Achilles tendon).
Psychiatric
- Frequency not reported: Acute psychosis (visual and auditory hallucinations, irrational speech, behavioral disturbances)[Ref]
At least 1 case of acute psychosis (visual and auditory hallucinations, irrational speech, and behavioral disturbances) has been reported after ocular administration. The symptoms resolved upon discontinuation.[Ref]
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References
1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
2. Cerner Multum, Inc. "Australian Product Information."
3. (2001) "Product Information. Ciloxan (ciprofloxacin ophthalmic)." Alcon Laboratories Inc
4. Wilhelmus KR, Abshire RL (2003) "Corneal ciprofloxacin precipitation during bacterial keratitis." Am J Ophthalmol, 136, p. 1032-7
5. Tripathi A, Chen SI, O'Sullivan S (2002) "Clinicopathologic reports, case reports, and small case series: acute psychosis following the use of topical ciprofloxacin." Arch Ophthalmol, 120, p. 669-70
More about Ciloxan (ciprofloxacin ophthalmic)
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Further information
Ciloxan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.