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Chlorpheniramine / dextromethorphan / methscopolamine Side Effects

For the Consumer

Applies to chlorpheniramine / dextromethorphan / methscopolamine: tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; change in appetite; constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; lightheadedness; nausea; nervousness; restlessness; stomach upset or pain; tiredness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking chlorpheniramine / dextromethorphan / methscopolamine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty swallowing; difficulty urinating; fast, slow, or irregular heartbeat; flushing; hallucinations; increased irritability or excitability; memory problems; seizures; severe clumsiness; severe dizziness, drowsiness, headache, or lightheadedness; sore throat; unusual tiredness or weakness; vision changes.

For Healthcare Professionals

Applies to chlorpheniramine / dextromethorphan / methscopolamine: oral tablet extended release

Cardiovascular

Cardiovascular side effects have included bradycardia, tachycardia, flushing, and, palpitations.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea, xerostomia, diarrhea, abdominal pain, appetite increase, weight gain, constipation, and dysphagia.[Ref]

Ocular

Ocular side effects have included mydriasis, diplopia, and blurred vision.[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia and weakness.[Ref]

Nervous system

Nervous system side effects have included headache, excitability, irritability, fatigue, nervousness, dizziness, drowsiness, confusion, and memory impairment.[Ref]

Genitourinary

Genitourinary side effects have included urinary retention.[Ref]

Renal

Renal side effects have included polyuria.[Ref]

Respiratory

Respiratory side effects have included pharyngitis.[Ref]

References

1. "Product Information. Extendryl DM (chlorpheniramine/DM/methscopolamine)." Aura Laboratories, Fort Lauderdale, FL.

Not all side effects for chlorpheniramine / dextromethorphan / methscopolamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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