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Chlorcyclizine / codeine Side Effects

For the Consumer

Applies to chlorcyclizine / codeine: oral liquid

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Stop using this medicine and call your doctor at once if you have:

  • severe dizziness, restless feeling, or nervousness;

  • little or no urinating; or

  • severe stomach cramps or constipation.

Common side effects may include:

  • drowsiness;

  • mild constipation; or

  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlorcyclizine / codeine: oral liquid

General

The most common side effects may include drowsiness, dizziness, and dry mouth.[Ref]

Respiratory

Frequency not reported: Respiratory depression

Gastrointestinal

Frequency not reported: Nausea, vomiting, constipation[Ref]

Psychiatric

Frequency not reported: Excitability

Nervous system

Frequency not reported: Drowsiness[Ref]

Cardiovascular

Frequency not reported: Hypotension, dizziness[Ref]

Dermatologic

Frequency not reported: Rashes, severe scarlatiniform eruptions, generalized dermatitis[Ref]

Genitourinary

Frequency not reported: Urinary retention[Ref]

Ocular

Frequency not reported: Blurred vision,

Antihistamines:
Frequency not reported: Worsening of closed-angle glaucoma (also called narrow-angle or angle-closure glaucoma)[Ref]

References

1. American Geriatrics Society 2012 Beers Criteria Update Expert Panel "American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults." J Am Geriatr Soc 60 (2012): 616-31

2. "Product Information. Codeine Sulfate (codeine)." Roxane Laboratories Inc, Columbus, OH.

3. Stringer MD, Greenfield S, McIrvine AJ "Stercoral perforation of the colon following postoperative analgesia." J R Soc Med 80 (1987): 115-6

4. Stambaugh JE Jr, McAdams J "Comparison of the analgesic efficacy and safety of oral ciramadol, codeine, and placebo in patients with chronic cancer pain." J Clin Pharmacol 27 (1987): 162-6

5. Max MB, Schafer SC, Culnane M, et al "Association of pain relief with drug side effects in postherpeticneuralgia: a single-dose study of clonidine, codeine, ibuprofen, and placebo." Clin Pharmacol Ther 43 (1988): 363-71

6. "Product Information. Notuss-NX (chlorcyclizine-codeine)." SJ Pharmaceuticals formerly Stewart-Jackson Pharmacal Inc, Atlanta, GA.

7. de Groot AC, Conemans J "Allergic urticarial rash from oral codeine." Contact Dermatitis 14 (1986): 209-14

8. Hastier P, Buckley MJM, Peten EP, Demuth N, Dumas R, Demarquay JF, CaroliBosc FX, Delmont JP "A new source of drug-induced acute pancreatitis: Codeine." Am J Gastroenterol 95 (2000): 3295-8

9. Shorr RI, Griffin MR, Daugherty JR, Ray WA "Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene." J Gerontol 47 (1992): m111-5

10. Bradley CM, Nicholson AN "Effects of a mu-opoiod receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man." Br J Clin Pharmacol 22 (1986): 507-12

11. Cox RG "Hypoxaemia and hypotension after intravenous codeine phosphate." Can J Anaesth 41 (1994): 1211-3

12. Redpath JB, Pleuvry BJ "Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers." Br J Clin Pharmacol 14 (1982): 555-8

13. Zolezzi M, Al Mohaimeed SA "Seizures with intravenous codeine phosphate." Ann Pharmacother 35 (2001): 1211-3

14. Malek-Ahmadi P, Ramsey ML "Acute psychosis associated with codeine and acetaminophen: a case report." Neurobehav Toxicol Teratol 7 (1985): 193-4

15. Parke TJ, Nandi PR, Bird KJ, Jewkes DA "Profound hypotension following intravenous codeine phosphate: three case reports and some recommendations." Anaesthesia 47 (1992): 852-4

16. Rodriguez F, Fernandez L, Garciaabujeta JL, Maquiera E, Llaca HF, Jerez J "Generalized dermatitis due to codeine." Contact Dermatitis 32 (1995): 120

17. Gonzalogarijo MA, Revengaarranz F "Fixed drug eruption due to codeine." Br J Dermatol 135 (1996): 498-9

18. Hunskaar S, Dragsund S "Scarlatiniform rash and urticaria due to codeine." Ann Allergy 54 (1985): 240-1

19. Knaggs RD, Crighton IM, Cobby TF, Fletcher AJ, Hobbs GJ "The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers." Anesth Analg 99 (2004): 108-12

Some side effects of chlorcyclizine / codeine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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