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Chlorcyclizine / codeine / pseudoephedrine Side Effects

Applies to chlorcyclizine/codeine/pseudoephedrine: oral liquid.


Codeine may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Medicines that contain codeine should not be given to a child just after surgery to remove the tonsils or adenoids. Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Get emergency medical help if a child taking this medicine has breathing problems, blue lips, or severe drowsiness, or if you cannot wake the child up from sleep.

Stop using chlorcyclizine, codeine, and pseudoephedrine and call your doctor at once if you have:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlorcyclizine / codeine / pseudoephedrine: oral liquid.


The most common side effects may include drowsiness, dizziness, dry mouth, and nervousness.[Ref]


Frequency not reported: Respiratory depression


Frequency not reported: Excitability, nervousness, insomnia

Nervous system

Frequency not reported: Drowsiness[Ref]


Frequency not reported: Hypotension, dizziness[Ref]


Frequency not reported: Nausea, vomiting, constipation , dry mouth[Ref]


Frequency not reported: Urinary retention[Ref]


Frequency not reported: Blurred vision[Ref]


Frequency not reported: Rashes, severe scarlatiniform eruptions, generalized dermatitis[Ref]


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2. Redpath JB, Pleuvry BJ (1982) "Double-blind comparison of the respiratory and sedative effects of codeine phosphate and (+/-)-glaucine phosphate in human volunteers." Br J Clin Pharmacol, 14, p. 555-8

3. Bradley CM, Nicholson AN (1986) "Effects of a mu-opoiod receptor agonist (codeine phosphate) on visuo-motor coordination and dynamic visual acuity in man." Br J Clin Pharmacol, 22, p. 507-12

4. de Groot AC, Conemans J (1986) "Allergic urticarial rash from oral codeine." Contact Dermatitis, 14, p. 209-14

5. Malek-Ahmadi P, Ramsey ML (1985) "Acute psychosis associated with codeine and acetaminophen: a case report." Neurobehav Toxicol Teratol, 7, p. 193-4

6. Stambaugh JE Jr, McAdams J (1987) "Comparison of the analgesic efficacy and safety of oral ciramadol, codeine, and placebo in patients with chronic cancer pain." J Clin Pharmacol, 27, p. 162-6

7. Max MB, Schafer SC, Culnane M, et al. (1988) "Association of pain relief with drug side effects in postherpeticneuralgia: a single-dose study of clonidine, codeine, ibuprofen, and placebo." Clin Pharmacol Ther, 43, p. 363-71

8. Shorr RI, Griffin MR, Daugherty JR, Ray WA (1992) "Opioid analgesics and the risk of hip fracture in the elderly: codeine and propoxyphene." J Gerontol, 47, m111-5

9. Cox RG (1994) "Hypoxaemia and hypotension after intravenous codeine phosphate." Can J Anaesth, 41, p. 1211-3

10. Zolezzi M, Al Mohaimeed SA (2001) "Seizures with intravenous codeine phosphate." Ann Pharmacother, 35, p. 1211-3

11. (2010) "Product Information. Notuss-NXD (chlorcyclizine / codeine / pseudoephedrine)." SJ Pharmaceuticals formerly Stewart-Jackson Pharmacal Inc

12. Parke TJ, Nandi PR, Bird KJ, Jewkes DA (1992) "Profound hypotension following intravenous codeine phosphate: three case reports and some recommendations." Anaesthesia, 47, p. 852-4

13. Stringer MD, Greenfield S, McIrvine AJ (1987) "Stercoral perforation of the colon following postoperative analgesia." J R Soc Med, 80, p. 115-6

14. Hastier P, Buckley MJM, Peten EP, Demuth N, Dumas R, Demarquay JF, CaroliBosc FX, Delmont JP (2000) "A new source of drug-induced acute pancreatitis: Codeine." Am J Gastroenterol, 95, p. 3295-8

15. Knaggs RD, Crighton IM, Cobby TF, Fletcher AJ, Hobbs GJ (2004) "The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers." Anesth Analg, 99, p. 108-12

16. Hunskaar S, Dragsund S (1985) "Scarlatiniform rash and urticaria due to codeine." Ann Allergy, 54, p. 240-1

17. Rodriguez F, Fernandez L, Garciaabujeta JL, Maquiera E, Llaca HF, Jerez J (1995) "Generalized dermatitis due to codeine." Contact Dermatitis, 32, p. 120

18. Gonzalogarijo MA, Revengaarranz F (1996) "Fixed drug eruption due to codeine." Br J Dermatol, 135, p. 498-9

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.