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Caffeine / magnesium salicylate Side Effects

Applies to caffeine / magnesium salicylate: oral tablet

Nervous system

Nervous system side effects associated with caffeine consumption have included central nervous system stimulation such as irritability, restlessness, and jitteriness. Tinnitus and subjective hearing loss (or both) may occur with salicylate. Some investigators have reported that modest doses may result in decreased frequency selectivity and may therefore impair hearing performance, particularly in the setting of background noise.[Ref]

Gastrointestinal

Gastrointestinal side effects of both caffeine and salicylate have included epigastric distress, abdominal discomfort or pain, nausea, and vomiting.[Ref]

Other

Other side effects have included Reye's syndrome with salicylate use in children with an acute viral illness. Reye's syndrome has also been reported even more rarely in adults.[Ref]

Cardiovascular

Cardiovascular side effects associated with caffeine products have rarely included tachycardia, increased left ventricular output, and increased stroke volume.[Ref]

General

In general, consumption of higher doses of caffeine (less than 600 mg/day) has been reported to have lead to caffeinism. Caffeinism is a syndrome characterized by anxiety, restlessness, and sleep disorders (similar to anxiety states). It has also been reported that chronic, heavy caffeine ingestion may be associated with depression. Caffeine may cause anxiety and panic in panic disorder patients and may aggravate premenstrual syndrome (PMS).[Ref]

Renal

Renal side effects associated with caffeine consumption have included increased urine flow rate, creatinine clearance, and sodium and calcium excretion.[Ref]

Respiratory

Respiratory side effects of salicylates have included bronchospastic reactions. Nonacetylated salicylates rarely cause reactions even in susceptible people when very large doses are given.

Hypersensitivity

Hypersensitivity side effects of magnesium salicylate include severe allergic reactions which may include hives, facial swelling, asthma, and shock.

References

1. "Product Information. Cafcit (caffeine)" Roxane Laboratories Inc, Columbus, OH.

2. Boettcher FA, Salvi RJ "Salicylate ototoxicity: review and synthesis." Am J Otolaryngol 12 (1991): 33-47

3. Thomas J, Straus WL, Bloom BS "Over-the-counter nonsteroidal anti-inflammatory drugs and risk of gastrointestinal symptoms." Am J Gastroenterol 97 (2002): 2215-9

4. Lanas A, Serrano P, Bajador E, Esteva F, Benito R, Sainz R "Evidence of aspirin use in both upper and lower gastrointestinal perforation." Gastroenterology 112 (1997): 683-9

5. "Product Information. Bayer aspirin (aspirin)." Bayer, West Haven, CT.

6. Belay ED, Bresee JS, Holman RC, Khan AS, Shahriari A, Schonberger LB "Reye's syndrome in the United States from 1981 through 1997." N Engl J Med 340 (1999): 1377-82

7. Sondermeijer H, van Marle A, Kamen P, Krum H "Acute effects of caffeine on heart rate variability." Am J Cardiol 90 (2002): 906

8. Hartley TR, Lovallo WR, Whitsett TL "Cardiovascular effects of caffeine in men and women." Am J Cardiol 93 (2004): 1022-6

9. Clementz GL, Dailey JW "Psychotropic effects of caffeine." Am Fam Physician 37 (1988): 167-72

10. Sawynok J "Pharmacological rationale for the clinical use of caffeine." Drugs 49 (1995): 37-50

Not all side effects for caffeine / magnesium salicylate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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