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Breztri Aerosphere Side Effects

Generic name: budesonide / formoterol / glycopyrrolate

Medically reviewed by Philip Thornton, DipPharm. Last updated on Oct 16, 2024.

Note: This document provides detailed information about Breztri Aerosphere.

Applies to budesonide / formoterol / glycopyrrolate: inhalation aerosol liquid Side Effects associated with budesonide / formoterol / glycopyrrolate. Some dosage forms listed on this page may not apply specifically to the brand name Breztri Aerosphere.

Applies to budesonide / formoterol / glycopyrrolate: inhalation aerosol liquid.

Precautions

It is very important that your doctor check your progress at regular visits to make sure the medicine is working properly. Blood and urine tests may be needed to check for any unwanted effects.

Tell your doctor if you are also using any other medicine for your COPD. Your doctor may want you to use it only during a severe COPD attack. Follow your doctor's instructions on how you should take your medicine.

This medicine should not be used if you are having a sudden COPD attack, or if symptoms of COPD attack has already started. Your doctor will give you a short-acting inhaler to use for this condition. If the short-acting inhaler is not working, tell your doctor right away.

Talk to your doctor or get medical care right away if:

Do not use this medicine together with other inhaled medicines for COPD, including arformoterol (Brovana®), formoterol (Foradil®, Perforomist®), indacaterol (Arcapta® Neohaler®), olodaterol, salmeterol (Serevent®), or vilanterol.

This medicine may increase the risk of worsening asthma, which may lead to hospitalization, intubation, and death, especially in patients with asthma who take bronchodilators without an inhaled steroid medicine. Talk to your doctor if you have concerns about this.

You may get infections more easily while using this medicine. Tell your doctor right away if you have been exposed to someone with chickenpox or measles.

This medicine may cause fungus infection of the mouth or throat (thrush). Tell your doctor right away if you have white patches in the mouth or throat, or pain when eating or swallowing.

Patients with COPD may be more likely to have pneumonia when using this medicine. Check with your doctor if you start having increased sputum (spit) production, change in sputum color, fever, chills, increased cough, or an increase in breathing problems.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause paradoxical bronchospasm, which may be life-threatening. Check with your doctor right away if you or your child are having a cough, difficulty with breathing, or wheezing.

If you develop a skin rash, hives, swelling of the tongue, lips, or face, or any allergic reaction to this medicine, check with your doctor right away.

This medicine may decrease bone mineral density when used for a long time. A low bone mineral density can cause weak bones or osteoporosis. If you have any questions about this, ask your doctor.

This medicine may cause heart or blood vessel problems, including heart rhythm problems. Check with your doctor right away if you have chest pain or tightness, decreased urine output, dilated neck veins, extreme fatigue, irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain.

Call your doctor right away if blurred vision, difficulty in reading, seeing halos around lights, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may affect blood sugar and potassium levels. If you notice a change in the results of your blood or urine sugar or potassium tests or if you have any questions, check with your doctor.

Check with your doctor right away if you have a decrease in urine volume, decrease in the frequency of urination, difficulty in passing urine, or painful urination.

Your doctor may want you to carry a medical identification (ID) card stating that you are using this medicine and that you may need additional medicine during times of emergency, a severe COPD attack or other illness, or unusual stress.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Breztri Aerosphere

Along with its needed effects, budesonide/formoterol/glycopyrrolate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking budesonide/formoterol/glycopyrrolate:

Less common side effects

  • bladder pain
  • bloody or cloudy urine
  • blurred vision
  • chest pain or tightness
  • chills
  • cough
  • darkening of the skin
  • decrease in urine volume and frequency of urination
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty breathing
  • dizziness
  • dry mouth
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • general feeling of discomfort or illness
  • headache
  • hives, itching, skin rash
  • hoarseness
  • increased hunger
  • increased thirst
  • increased urination
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • lower back or side pain
  • mental depression
  • muscle aches and pains
  • nausea
  • noisy breathing
  • pain or tenderness around the eyes and cheekbones
  • redness of the skin
  • shivering
  • sneezing
  • sore mouth, throat, or tongue
  • stomach pain
  • stuffy or runny nose
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tremor
  • trouble sleeping
  • trouble swallowing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
  • white patches in the mouth or on the tongue

Other side effects of Breztri Aerosphere

Some side effects of budesonide / formoterol / glycopyrrolate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • agitation
  • anxiety
  • back pain
  • bruising
  • muscle spasms
  • nervousness
  • restlessness
  • throat irritation

For healthcare professionals

Applies to budesonide / formoterol / glycopyrrolate: inhalation aerosol.

Respiratory adverse events

Budesonide-Containing Products (Orally Inhaled):

Inhaled Corticosteroids:

Long-Acting Beta2-Adrenergic Agonists (LABA):

Musculoskeletal

Inhaled Corticosteroids:

Gastrointestinal

Budesonide-Containing Products (Orally Inhaled):

Cardiovascular

Formoterol:

Beta-Agonists:

Inhaled Sympathomimetic Drugs:

Genitourinary

Nervous system

Psychiatric

Metabolic

Beta2-Adrenergic Agonists:

Hypersensitivity

Other

Dermatologic

Endocrine

Ocular

Inhaled Corticosteroids (Long-Term) or Inhaled Anticholinergics:

See also:

References

1. (2020) "Product Information. Breztri Aerosphere (budesonide / formoterol / glycopyrrolate)." Astra-Zeneca Pharmaceuticals

Frequently asked questions

Further information

Breztri Aerosphere side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.