BexxarTherapeutic Side Effects
Generic Name: tositumomab
Note: This page contains information about the side effects of tositumomab. Some of the dosage forms included on this document may not apply to the brand name BexxarTherapeutic.
For the Consumer
Applies to tositumomab: parenteral iodine i 131 tositumomab injection, parenteral tositumomab injection
Side effects include:
Neutropenia, thrombocytopenia, anemia, asthenia, infection, fever, nausea.
For Healthcare Professionals
Applies to tositumomab: intravenous kit
Common (1% to 10%): Hypotension, vasodilation[Ref]
Very common (10% or more): Rash, pruritus
Common (1% to 10%): Sweating[Ref]
Common (1% to 10%): Hypothyroidism[Ref]
Very common (10% or more): Abdominal pain, nausea, vomiting, diarrhea, anorexia
Common (1% to 10%): Constipation, dyspepsia[Ref]
Very common (10% or more): Neutropenia, thrombocytopenia, anemia[Ref]
Common (1% to 10%): Allergic (hypersensitivity) reactions (allergic reaction, facial edema, injection site hypersensitivity, anaphylactic reaction, laryngismus, serum sickness)
Postmarketing reports: Hypersensitivity reactions including fatal anaphylaxis[Ref]
Very common (10% or more): Positive serology for human anti-mouse antibodies (HAMA)[Ref]
Frequency not reported: Infusion reactions[Ref]
Common (1% to 10%): Peripheral edema, weight loss[Ref]
Very common (10% or more): Myalgia, arthralgia
Common (1% to 10%): Back pain, neck pain[Ref]
Common (1% to 10%): Dizziness, somnolence
Postmarketing reports: Axonal neuropathy leading to quadriparesis[Ref]
Common (1% to 10%): Secondary malignancies (non-melanoma skin, colorectal, head and neck, breast, lung, bladder, melanoma, gastric)
Frequency not reported: Secondary leukemia, myelodysplastic syndrome[Ref]
Very common (10% or more): Asthenia, fever, infections, pain, chills, headache
Common (1% to 10%): Chest pain, serious infections (pneumonia, bacteremia, septicemia, bronchitis, skin infections)[Ref]
Very common (10% or more): Cough, pharyngitis, dyspnea, rhinitis
Common (1% to 10%): Pneumonia[Ref]
1. "Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab)." GlaxoSmithKline, Research Triangle Park, NC.
2. "Product Information. BexxarTherapy (tositumomab)." GlaxoSmithKline Inc, Oakville, IA.
Not all side effects for BexxarTherapeutic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about BexxarTherapeutic (tositumomab)
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