Benzocaine / trimethobenzamide Side Effects
An isolated case report described a 50-year-old white female receiving trimethobenzamide capsules during a study protocol for use as a prophylactic antiemetic. After two days of administration, the patient had become jaundiced and her urine was dark. She felt tired, anorexic and nauseated with mild epigastric pain. A liver scan four days after the episode indicated hepatocellular dysfunction. She denied any other factors which may have contributed to the episode.[Ref]
Hypersensitivity side effects have included allergic-type skin reactions. Bronchospasm, shock, and anaphylactoid reactions may occur and, in general, have occurred with high plasma levels of the local anesthetic. Parkinson-like symptoms have been reported following the use of trimethobenzamide. These have abated following drug discontinuation, but in some cases treatment may be indicated.[Ref]
Musculoskeletal side effects have included muscle cramps associated with the use of trimethobenzamide.[Ref]
Extrapyramidal reactions to trimethobenzamide have been reported in some patients, the youngest of whom was 2 weeks old. This patient received approximately 300 mg rectally, although the drug is not recommended for newborn infants.[Ref]
Local side effects have included burning, stinging, tenderness, and sloughing following the use of benzocaine topical. Pain has been reported following the intramuscular administration of trimethobenzamide.[Ref]
Ocular side effects have included blurred vision following the use of trimethobenzamide.[Ref]
1. "Product Information. Tigan (trimethobenzamide)." Monarch Pharmaceuticals Inc, Bristol, TN.
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