Skip to Content

Benadryl-D Allergy Plus Sinus Side Effects

Generic Name: diphenhydramine / phenylephrine

Note: This document contains side effect information about diphenhydramine / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Benadryl-D Allergy Plus Sinus.

For the Consumer

Applies to diphenhydramine / phenylephrine: oral tablet chewable

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad dizziness or passing out.
  • A heartbeat that does not feel normal.
  • A fast heartbeat.
  • Feeling very tired or weak.
  • Any unexplained bruising or bleeding.
  • Change in balance.
  • Feeling confused.
  • Shakiness.
  • Change in eyesight.
  • Seizures.
  • Trouble passing urine.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Not able to sleep.
  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to diphenhydramine / phenylephrine: oral disintegrating strip, oral liquid, oral suspension extended release, oral tablet chewable extended release

Cardiovascular

Cardiovascular side effects have included hypotension, palpitations, tachycardia, and extrasystole.[Ref]

Hematologic

Hematologic side effects have included hemolytic anemia, agranulocytosis, and thrombocytopenia.[Ref]

Nervous system

Nervous system side effects have included sleepiness, sedation, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, headache, vertigo, tinnitus, acute labyrinthitis, neuritis, and convulsions.[Ref]

Ocular

Ocular side effects have included blurred vision and diplopia.[Ref]

Gastrointestinal

Gastrointestinal side effects have included epigastric distress, anorexia, nausea, vomiting, diarrhea, and constipation.[Ref]

Genitourinary

Genitourinary side effects have included urinary frequency, difficult urination, urinary retention, and early menses.[Ref]

Hypersensitivity

Hypersensitivity side effects have included urticaria, drug rash, anaphylactic shock, and photosensitivity.[Ref]

General

General side effects have included chills, excessive perspiration, and dryness of nose, throat and mouth.[Ref]

References

1. "Product Information. Dytan-D (diphenhydramine-phenylephrine)." Hawthorn Pharmaceuticals, Madison, MS.

Some side effects of Benadryl-D Allergy Plus Sinus may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide