Bempedoic acid / ezetimibe Side Effects
For the Consumer
Applies to bempedoic acid/ezetimibe: oral tablet
Some cholesterol medications should not be taken at the same time. If you take ezetimibe with another cholesterol medicine, follow your doctor's dosing instructions very carefully.
Get emergency medical help if you have signs of an allergic reaction: hives, rash, severe itching, skin redness or swelling; wheezing, difficult breathing, feeling light-headed; fast or pounding heartbeats; swelling of your face, lips, tongue, or throat.
Some side effects of bempedoic acid and ezetimibe can occur weeks or months after you have started taking this medicine.
Stop taking this medicine and get medical help right away if you have signs of tendon rupture--sudden pain, swelling, bruising, tenderness, stiffness, movement problems, or a snapping or popping sound in any of your joints (rest the joint until you receive medical care or instructions).
Call your doctor at once if you have:
low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
symptoms of gout--joint pain or swelling, warmth or redness around your joints, severe foot or toe pain.
Common side effects may include:
stomach pain, diarrhea;
cough, chest tightness, shortness of breath;
muscle spasm, back pain, joint pain;
pain in your shoulder, arms, or legs;
abnormal liver function tests;
cold or flu symptoms such as fever, chills, body aches, stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to bempedoic acid / ezetimibe: oral tablet
The most commonly reported adverse reactions have included upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes, diarrhea, arthralgia, sinusitis, fatigue, and influenza[Ref]
Approximately 10.1% of patients had an increase in platelet count of 100x10(9)/L or more on 1 or more occasion of receiving bempedoic acid compared to 4.7% receiving placebo. Platelet count elevations appeared to be asymptomatic as they did not result in an increased risk of thromboembolic events or require medical intervention.
Common (1% to 10%): Anemia, decreased leukocytes, increased platelet counts
Postmarketing reports: Thrombocytopenia
Gout occurred in 1.5% of patients receiving this drug compared to 0% of placebo-treated patients.
Very common (10% or more): Hyperuricemia (26%)
Common (1% to 10%): Clinically significant hyperuricemia, gout
Uncommon (0.1% to 1%): Increase in creatine kinase
Common (1% to 10%): Upper respiratory tract infection, bronchitis
Common (1% to 10%): Upper respiratory tract infection, sinusitis
Common (1% to 10%): Muscle spasms, back pain, extremity pain
Uncommon (0.1% to 1%): Tendon rupture
Postmarketing reports: Myalgia, elevated creatine phosphokinase, myopathy/rhabdomyolysis
Common (1% to 10%): Elevated liver enzymes
Common (1% to 10%): Constipation
Common (1% to 10%): Abdominal pain or discomfort
Frequency not reported: Diarrhea
Common (1% to 10%): Diarrhea
Common (1% to 10%): Urinary tract infection
Common (1% to 10%): Benign prostatic hyperplasia
Benign prostatic hyperplasia or prostatomegaly was reported in 1.3% of patients receiving bempedoic acid versus 0.1% in placebo patients.
Common (1% to 10%): Influenza
Postmarketing reports: Depression
Atrial fibrillation was reported in 1.7% of patients receiving bempedoic acid compared with 1.1% of placebo-treated patients.
Common (1% to 10%): Atrial fibrillation
Rare (less than 0.1%): Cellulitis
Postmarketing reports: Rash, erythema multiforme
Frequency not reported: Oral discomfort
Common (1% to 10%): Fatigue
Common (1% to 10%): Increased BUN, increased creatinine values
1. "Product Information. Nexlizet (bempedoic acid-ezetimibe)." Esperion Therapeutics, Ann Arbor, MI.
More about bempedoic acid / ezetimibe
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: antihyperlipidemic combinations
- Other brands
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.