Beleodaq Side Effects

Generic name: belinostat

Medically reviewed by Drugs.com. Last updated on Dec 30, 2024.

Note: This document provides detailed information about Beleodaq.

Applies to belinostat: intravenous powder for solution Side Effects associated with belinostat. Some dosage forms listed on this page may not apply specifically to the brand name Beleodaq.

Applies to belinostat: intravenous powder for solution.

Precautions

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 6 months after your last dose. Males who are taking this medicine, with female partners who can become pregnant must use effective birth control during and for at least 3 months after the last dose of this medicine. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine can temporarily lower the number of white blood cells and platelets in your blood, increasing the chance of getting an infection. Avoid being near people who are sick or have infections. Wash your hands often. Tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back. Check with your doctor right away if you think you are getting an infection or if you have a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness.

Belinostat can cause diarrhea, nausea, or vomiting. Your doctor may give you medicines to help prevent this. Call your doctor if you continue to have diarrhea, nausea, or vomiting after your dose.

If you plan to have children, talk with your doctor before using this medicine. Some men using this medicine have become infertile (unable to have children).

Serious side effects of Beleodaq

Along with its needed effects, belinostat (the active ingredient contained in Beleodaq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking belinostat:

Other side effects of Beleodaq

Some side effects of belinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to belinostat: intravenous powder for injection.

General adverse events

The most commonly observed adverse reactions included nausea, fatigue, pyrexia, anemia, and vomiting.

The most commonly reported reasons for treatment discontinuation included anemia, febrile neutropenia, fatigue, and multi-organ failure.^[Ref]

Hematologic

• Very common (10% or more): Anemia (32%), thrombocytopenia (16%)^[Ref]

Cardiovascular

• Very common (10% or more): Peripheral edema (20%), prolonged QT (11%), hypotension (10%), phlebitis (10%)^[Ref]

Dermatologic

• Very common (10% or more): Rash (20%), pruritus (16%)^[Ref]

Gastrointestinal

• Very common (10% or more): Nausea (43%), vomiting (29%), constipation (23%), diarrhea (23%), decreased appetite (15%), abdominal pain (11%)^[Ref]

Metabolic

• Very common (10% or more): Hypokalemia (12%)^[Ref]

Nervous system

• Very common (10% or more): Headache (15%), dizziness (10%)^[Ref]

Other

• Very common (10% or more): Fatigue (37%), pyrexia (35%), chills (16%)^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (22%), cough (19%)^[Ref]

See also:

Further information

Beleodaq side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer