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Beleodaq Side Effects

Generic Name: belinostat

Note: This page contains information about the side effects of belinostat. Some of the dosage forms included on this document may not apply to the brand name Beleodaq.

For the Consumer

Applies to belinostat: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by belinostat (the active ingredient contained in Beleodaq). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking belinostat, check with your doctor or nurse immediately:

More common:
  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • bluish color
  • blurred vision
  • changes in skin color
  • chest pain
  • confusion
  • cough
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast heartbeat
  • fever or chills
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • rapid, shallow breathing
  • sore throat
  • sweating
  • tenderness
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
Incidence not known:
  • Abdominal or stomach pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • headache
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • skin rash or itching
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with belinostat may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Constipation
  • diarrhea
  • dizziness
  • pain at the injection site

For Healthcare Professionals

Applies to belinostat: intravenous powder for injection


The most commonly observed adverse reactions included nausea, fatigue, pyrexia, anemia, and vomiting.

The most commonly reported reasons for treatment discontinuation included anemia, febrile neutropenia, fatigue, and multi-organ failure.[Ref]


Very common (10% or more): Anemia (32%), thrombocytopenia (16%)[Ref]


Very common (10% or more): Peripheral edema (20%), prolonged QT (11%), hypotension (10%), phlebitis (10%)[Ref]


Very common (10% or more): Rash (20%), pruritus (16%)[Ref]


Very common (10% or more): Nausea (43%), vomiting (29%), constipation (23%), diarrhea (23%), decreased appetite (15%), abdominal pain (11%)[Ref]


Very common (10% or more): Hypokalemia (12%)[Ref]

Nervous system

Very common (10% or more): Headache (15%), dizziness (10%)[Ref]


Very common (10% or more): Fatigue (37%), pyrexia (35%), chills (16%)[Ref]


Very common (10% or more): Dyspnea (22%), cough (19%)[Ref]


1. "Product Information. Beleodaq (belinostat)." Spectrum Pharmaceuticals Inc, Irvine, CA.

Not all side effects for Beleodaq may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.