Skip to main content

Beleodaq

Generic name: belinostatbe-LIN-oh-stat ]
Drug class: Histone deacetylase inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jan 16, 2024.

What is Beleodaq?

Beleodaq is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Beleodaq injection is used to treat peripheral T-cell lymphoma after other cancer treatments did not work or have stopped working.

Beleodaq was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, non-small cell lung tumors responded to this medicine. However, it has not been shown that belinostat can improve symptoms or lengthen survival time.

Warnings

Beleodaq affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, flu-like symptoms, or unusual bleeding or bruising.

Belinostat can harm your unborn baby. You should not become pregnant while receiving Beleodaq. Tell your doctor right away if you become pregnant while receiving this medicine.

Before taking this medicine

To make sure Beleodaq is safe for you, tell your doctor if you have ever had:

Belinostat can harm an unborn baby if the mother or the father is using this medicine.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

How is Beleodaq given?

Beleodaq injection is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take at least 30 minutes to complete.

Beleodaq is given in a 21-day treatment cycle. You may need to use the medicine only during the first 5 days of each cycle. Your doctor will determine how long to treat you with this medicine.

You may be given medication to prevent nausea, vomiting, or diarrhea while you are receiving Beleodaq.

Belinostat affects your immune system. You may get infections more easily, even serious or fatal infections.

Your blood will need to be tested every week during each treatment cycle. Your cancer treatments may be delayed based on the results.

Dosing information

Usual Adult Dose for Lymphoma:

1,000 mg/m2 IV over 30 minutes once daily on days 1 to 5 of a 21-day cycle

Duration of therapy: Repeat cycle every 21 days until disease progression or unacceptable toxicity.

Comments:
-Dose reduction, discontinuation, or interruption of therapy may be needed to manage adverse reactions.

Use: Relapsed or refractory peripheral T-cell lymphoma

prednisone, methotrexate, dexamethasone, Decadron, Revlimid, Velcade, romidepsin, Folotyn, pralatrexate, belinostat

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Beleodaq injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Beleodaq?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Beleodaq side effects

Get emergency medical help if you have signs of an allergic reaction to Beleodaq: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

Common Beleodaq side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Beleodaq?

Other drugs may interact with belinostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does Beleodaq interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Beleodaq only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.