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Histone deacetylase inhibitors

What are Histone deacetylase inhibitors?

Histone deacetylase (HDAC) inhibitors are a group of agents that inhibit the histone deactylase enzymes. During gene expression DNA coils and uncoils around histones. Histone acetylases, acetylate the lysine residues in core histones and histone deactylases remove the acetyl groups from the lysine residues. These actions are important in the regulation of gene expression.

Histone deacetylase inhibitors prevent the deactylation, affect gene expression and causes apoptosis of tumor cells. Histone deacetylase inhibitors are used to treat cutaneous T-cell lymphoma.

List of Histone deacetylase inhibitors

View by  Brand | Generic
Drug Name Avg. Rating Reviews
Istodax (Pro)
Generic name: romidepsin
1 review
Zolinza (Pro)
Generic name: vorinostat
No reviews
Farydak (Pro)
Generic name: panobinostat
No reviews
Generic name: belinostat
No reviews
For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).

See also

Medical conditions associated with histone deacetylase inhibitors:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.