Histone deacetylase inhibitors
What are Histone deacetylase inhibitors?
Histone deacetylase (HDAC) inhibitors are a group of agents that inhibit the histone deactylase enzymes. During gene expression DNA coils and uncoils around histones. Histone acetylases, acetylate the lysine residues in core histones and histone deactylases remove the acetyl groups from the lysine residues. These actions are important in the regulation of gene expression.
Histone deacetylase inhibitors prevent the deactylation, affect gene expression and causes apoptosis of tumor cells. Histone deacetylase inhibitors are used to treat cutaneous T-cell lymphoma.
List of Histone deacetylase inhibitors
| Drug Name | Avg. Rating | Reviews |
|---|---|---|
| romidepsin systemic (Pro) Brand name: Istodax |
1 review | |
| vorinostat systemic (Pro) Brand name: Zolinza | No reviews | |
| givinostat systemic (Pro) Brand name: Duvyzat | No reviews | |
| belinostat systemic (Pro) Brand name: Beleodaq | No reviews | |
| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). | ||
See also
Medical conditions treated or associated with histone deacetylase inhibitors:
Further information
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