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Barbidonna Side Effects

Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine

Note: This document contains side effect information about atropine / hyoscyamine / phenobarbital / scopolamine. Some of the dosage forms listed on this page may not apply to the brand name Barbidonna.

For the Consumer

Applies to atropine / hyoscyamine / phenobarbital / scopolamine: oral capsule, oral elixir, oral liquid, oral tablet, oral tablet extended release

Along with its needed effects, atropine / hyoscyamine / phenobarbital / scopolamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atropine / hyoscyamine / phenobarbital / scopolamine:

  • Eye pain
  • skin rash or hives
  • sore throat and fever
  • unusual bleeding or bruising
  • yellow eyes or skin

Some side effects of atropine / hyoscyamine / phenobarbital / scopolamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Constipation
  • decreased sweating
  • dizziness
  • dry mouth, nose, throat, or skin
Less common or rare
  • Bloated feeling
  • blurred vision
  • decreased flow of breast milk
  • difficult urination
  • difficulty in swallowing
  • headache
  • increased sensitivity of eyes to sunlight
  • loss of memory
  • nausea or vomiting
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to atropine / hyoscyamine / phenobarbital / scopolamine: oral capsule, oral elixir, oral liquid, oral tablet, oral tablet extended release


Gastrointestinal side effects have included xerostomia, nausea, vomiting, constipation, and bloating.[Ref]


Genitourinary side effects have included urinary hesitancy, urinary retention, and impotence.[Ref]


Cardiovascular side effects have included tachycardia and palpitation.[Ref]


Ocular side effects have included blurred vision, mydriasis, cycloplegia, and increased ocular tension.[Ref]


Hypersensitivity reactions have included severe allergic reactions, anaphylaxis, urticaria, and other dermal manifestations.[Ref]


Endocrine side effects have included suppression of lactation.[Ref]


Musculoskeletal side effects have included musculoskeletal pain.[Ref]

Nervous system

Nervous system side effects have included headache, excitement, and agitation.[Ref]


Psychiatric side effects have included excitement in some patients and sedation in other patients with use of phenobarbital. Abrupt withdrawal from phenobarbital may produce delirium or convulsions.[Ref]


General side effects have included drowsiness, weakness, loss of taste sense, decreased sweating, and insomnia. Elderly patients may react with symptoms of excitement, agitation, drowsiness, and other untoward manifestations to even small doses of the drug.[Ref]


1. "Product Information. Donnatal (atropine/hyoscyamine/PB/scopolamine)." Allscripts Healthcare Solutions, Libertyville, IL.

Some side effects of Barbidonna may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.