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Bactramycin Side Effects

Generic Name: lincomycin

Note: This page contains information about the side effects of lincomycin. Some of the dosage forms included on this document may not apply to the brand name Bactramycin.

For the Consumer

Applies to lincomycin: capsule, solution

In addition to its needed effects, some unwanted effects may be caused by lincomycin (the active ingredient contained in Bactramycin). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking lincomycin:

More common:
  • Abdominal or stomach cramps and pain (severe)
  • abdominal tenderness
  • diarrhea (watery and severe), which may also be bloody
  • fever
Less common:
  • Skin rash, redness, and itching
  • sore throat and fever
  • unusual bleeding and bruising

Note: Some of the above side effects may also occur up to several weeks after you Stop taking lincomycin.

Minor Side Effects

Some of the side effects that can occur with lincomycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea (mild)
  • nausea and vomiting
  • stomach pain
Less common:
  • Itching of rectal or genital (sex organ) areas

For Healthcare Professionals

Applies to lincomycin: compounding powder, injectable solution, oral capsule


The onset of pseudomembranous colitis symptoms has been reported during and after antibacterial therapy.

Esophagitis was reported with oral preparations.[Ref]

Frequency not reported: Glossitis, stomatitis, nausea, vomiting, abdominal distress, persistent diarrhea, enterocolitis, antibacterial-associated diarrhea and colitis, pruritus ani, pseudomembranous colitis, Clostridium difficile associated diarrhea, esophagitis[Ref]


Some hypersensitivity reactions occurred in penicillin-sensitive patients.

A 19-year-old male patient, who had received 2 previous IM injections of lincomycin (the active ingredient contained in Bactramycin) at the age of 17 years and 1 IM injection 2 weeks prior, reported that a few minutes after his fourth IM injection he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone IM followed by oral prednisone with an antihistamine.[Ref]

Frequency not reported: Hypersensitivity reactions (such as angioneurotic edema, serum sickness, anaphylaxis); face, ears, and neck swelling[Ref]


Rare (less than 0.1%): Exfoliative and vesiculobullous dermatitis
Frequency not reported: Skin rashes, urticaria, pruritus, erythema multiforme (some resembling Stevens-Johnson syndrome)[Ref]


Rare (less than 0.1%): Aplastic anemia, pancytopenia
Frequency not reported: Neutropenia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura[Ref]


Rare (less than 0.1%): Cardiopulmonary arrest
Frequency not reported: Hypotension[Ref]

Cases of hypotension after parenteral administration have been reported, especially after too rapid IV administration. Rare cases of cardiopulmonary arrest have been reported after this drug was administered IV too rapidly. In these cases, the affected patients subsequently tolerated slow infusions. A study that looked at multiple large dose administration of this drug found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.[Ref]


Frequency not reported: Jaundice, abnormal liver function tests (especially elevated serum transaminase)[Ref]


Rare (less than 0.1%): Renal dysfunction, azotemia, oliguria[Ref]


Rare (less than 0.1%): Proteinuria
Frequency not reported: Vaginitis[Ref]

Nervous system

Frequency not reported: Tinnitus, vertigo, neuromuscular blockade, metallic taste in mouth[Ref]


Frequency not reported:
-IM: Pain following injection, local irritation, pain induration, sterile abscess formation
-IV: Thrombophlebitis[Ref]


Frequency not reported: Bulbar conjunctival injection


1. Novak E, Vitti TG, Panzer JD, Schlagel C, Hearron MS "Antibiotic tolerance and serum levels after intravenous administration of multiple large doses of lincomycin." Clin Pharmacol Ther 12 (1971): 793-7

2. Jaimes EC "Lincocinamides and the incidence of antibiotic-associated colitis." Clin Ther 13 (1991): 270-80

3. Mickal A, Dildy GA, Miller HJ "Lincomycin in the treatment of cervicitis and vagini in pregnancy." South Med J 59 (1966): 567-70

4. Marks MI, Shapera RM, Brazeau M "Pediatric antimicrobial therapy 3." Can Med Assoc J 109 (1973): 213-4

5. Burbige EJ, Milligan FD "Pseudomembranous colitis. Association with antibiotics and therapy with cholestyramine." JAMA 231 (1975): 1157-8

6. Scott AJ, Nicholson GI "The recognition of pseudomembranous colitis as a clinical entity." Aust N Z J Med 4 (1974): 502-9

7. Wilson DH, Cunliffe WJ, Tan SG "Letter: Lincomycin and clindamycin colitis." Br Med J 4 (1974): 288-9

8. Bartlett JG "Anti-anaerobic antibacterial agents." Lancet 2 (1982): 478-81

9. Hamilton-Miller JM "Antimicrobial agents acting against anaerobes." J Antimicrob Chemother 1 (1975): 273-89

10. Venning GR "Identification of adverse reactions to new drugs. II (continued): How were 18 important adverse reactions discovered and with what delays?" Br Med J (Clin Res Ed) 286 (1983): 365-8

11. "Letter: Lincomycin and clindamycin colitis." Br Med J 4 (1974): 591

12. Berry DD, Brouhard BH, Box QT "Adverse reactions to parenteral lincomycin." Pediatrics 67 (1981): 389-91

13. Ashton H, Beveridge GW, Stevenson CJ "Lincomycin and clindamycin." Br J Dermatol 83 (1970): 604-6

14. Keighley MR, Arabi Y, Matheson D, Alexander-Williams J "Aspects of preventing sepsis in colo-rectal surgery: results of recent clinical trials." J Antimicrob Chemother 4 Suppl C (1978): 33-8

15. Gibson GE, Rowland R, Hecker R "Diarrhoea and colitis associated with antibiotic treatment." Aust N Z J Med 5 (1975): 340-7

16. "Lincomycin and clindamycin colitis." Br Med J 4 (1974): 65-6

17. Phillips I "Past and current use of clindamycin and lincomycin." J Antimicrob Chemother 7 Suppl A (1981): 11-8

18. Munk JF, Collopy BT, Connell JL, et al. "Lincomycin-clindamycin-associated psuedomembranous colitis." Med J Aust 2 (1976): 95-7

19. Robertson MB, Breen KJ, Desmond PV, Mashford ML, McHugh AM "Incidence of antibiotic-related diarrhoea and pseudomembranous colitis: a prospective study of lincomycin, clindamycin and ampicillin." Med J Aust 1 (1977): 243-6

20. "The macrolides and lincomycin." Br Med J 3 (1968): 233-4

21. Lambert HP "Unwanted effects of antibiotics: some recent additions." J Antimicrob Chemother 1 (1975): 2-4

22. Burdon DW "Prophylaxis in surgery." J Antimicrob Chemother 7 Suppl A (1981): 19-25

23. Crapp AR, Powis J, Clark C, Keighley MR, Alexander-Williams J "Letter: Postoperative pseudomembranous colitis." Br Med J 3 (1975): 227

24. Price DJ, O'Grady FW, Shooter RA, Weaver PC "Trial of phenyoxymethylpenicillin, phenethicillin, and lincomycin in treatment of staphylococcal sepsis in a casualty department." Br Med J 2 (1968): 407-9

25. McCool D, Miller RR "Treatment of lincomycin-caused diarrhea." JAMA 236 (1976): 1937-8

26. Kinsella PL "Letter: Antibiotic diarrhoea." Br Med J 4 (1975): 580

27. George WL, Sutter VL, Finegold SM "Antimicrobial agent-induced diarrhea--a bacterial disease." J Infect Dis 136 (1977): 822-8

28. Clark CE, Thompson H, Mcleish AR, Powis SJ, Dorricott NJ, Alexander-Williams J "Pseudomembranous colitis following prophylactic antibiotics in bowel surgery." J Antimicrob Chemother 2 (1976): 167-73

29. "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn, Kalamazoo, MI.

30. Sanders E "Lincomycin versus erythromycin: a choice or an echo." Ann Intern Med 70 (1969): 585-90

31. Viteri AL, Howard PH, Dyck WP "The spectrum of lincomycin-clindamycin colitis." Gastroenterology 66 (1974): 1137-44

32. Scott AJ, Nicholson GI, Kerr AR "Lincomycin as a cause of pseudomembranous colitis." Lancet 2 (1973): 1232-4

33. Parsons RL, Beavis JP, Salfield JB "Letter: Diarrhoea and colitis associated with antibiotic therapy." Br Med J 4 (1975): 42

34. Pittman FE, Pittman JC, Humphrey CD "Letter: Lincomycin and pseudomembranous colitis." Lancet 1 (1974): 451-2

35. Bartlett JG, Sutter VL, Finegold SM "Treatment of anaerobic infections with lincomycin and clindamycin." N Engl J Med 287 (1972): 1006-10

36. Boyd WC, DenBesten L "Subtotal colectomy for refractory pseudomembranous enterocolitis." JAMA 235 (1976): 181

37. Kaplan K, Weinstein L "Lincomycin." Pediatr Clin North Am 15 (1968): 131-9

38. Liner SR "Adverse reactions to parenteral lincomycin." Pediatrics 68 (1981): 615-6

39. Mohr JA, Rhoades ER, Muchmore HG "Actinomycosis treated with lincomycin." JAMA 212 (1970): 2260-2

40. Walker WG "Hypersensitivity reaction in a patient receiving lincomycin." Can Med Assoc J 101 (1969): 130

41. Duncan IB, Jeans B "Lincomycin in hospital practice." Can Med Assoc J 93 (1965): 685-91

42. Brown EB, Cunningham CE "Granulocytopenia occurring during the administration of lincomycin." JAMA 194 (1965): 668-70

43. Raff MJ "Lincomycin: thrombocytopenia?" Ann Intern Med 78 (1973): 779

44. Daubeck JL, Daughety MJ, Petty C "Lincomycin-induced cardiac arrest: a case report and laboratory investigation." Anesth Analg 53 (1974): 563-7

45. Waisbren BA "Lincomycin in larger doses." JAMA 206 (1968): 2118

46. Darrell JH, Uttley AH "Antibiotics in the peri-operative period." Br J Anaesth 48 (1976): 13-9

47. Samuelson RJ, Giesecke AT Jr, Kallus FT, Stanley VF "Lincomycin-curare interaction." Anesth Analg 54 (1975): 103-5

48. Duignan NM, Andrews J, Williams JD "Pharmacological studies with lincomycin in late pregnancy." Br Med J 3 (1973): 75-8

49. Snavely SR, Hodges GR "The neurotoxicity of antibacterial agents." Ann Intern Med 101 (1984): 92-104

Not all side effects for Bactramycin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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