Bactocill Side Effects
Generic name: oxacillin
Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.
Note: This document contains side effect information about oxacillin. Some of the dosage forms listed on this page may not apply to the brand name Bactocill.
For the Consumer
Applies to oxacillin: parenteral injection, parenteral powder for injection
Side effects include:
Hypersensitivity reactions; local reactions (phlebitis, thrombophlebitis); renal, hepatic, or nervous system effects with high dosage.
For Healthcare Professionals
Applies to oxacillin: injectable powder for injection, intravenous solution, oral capsule, oral powder for reconstitution
Immediate allergic reactions usually occurred within 20 minutes of administration and ranged in severity from urticaria and pruritus to angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse, and death; such immediate anaphylactic reactions were very rare and usually occurred after parenteral therapy but have occurred with oral therapy. An accelerated immediate allergic reaction has occurred between 20 minutes and 48 hours after administration and has included urticaria, pruritus, and fever; although laryngeal edema, laryngospasm, and hypotension occasionally occurred, fatality was uncommon.
Delayed allergic reactions to penicillin therapy usually occurred after 48 hours and sometimes as late as 2 to 4 weeks after starting therapy. Manifestations of this reaction included serum sickness-like symptoms (i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain) and various skin rashes.[Ref]
Common (1% to 10%): Allergic reactions (included immediate and delayed reactions)
Rare (0.01% to 0.1%): Anaphylactic shock
Very rare (less than 0.01%): Anaphylactic shock resulting in death
Frequency not reported: Immediate allergic reaction (included urticaria, pruritus, angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse, death), accelerated immediate allergic reaction (included urticaria, pruritus, fever, laryngeal edema, laryngospasm, hypotension), delayed allergic reaction (included serum sickness-like reactions [i.e., fever, malaise, urticaria, myalgia, arthralgia, abdominal pain], various skin rashes), anaphylaxis[Ref]
Frequency not reported: Rash, urticaria, pruritus[Ref]
Neurotoxic reactions (similar to those observed with penicillin G) have occurred with large IV doses, especially in patients with renal dysfunction.[Ref]
Frequency not reported: Fever, abnormal alkaline phosphatase serum levels[Ref]
Frequency not reported: Renal tubular damage, interstitial nephritis, renal insufficiency, nephropathy, acute renal failure[Ref]
Frequency not reported: Thrombophlebitis, tissue necrosis after extravasation[Ref]
More about Bactocill (oxacillin)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Drug class: penicillinase resistant penicillins
Related treatment guides
1. "Product Information. Bactocill (oxacillin)." SmithKline Beecham, Philadelphia, PA.
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Some side effects may not be reported. You may report them to the FDA.