Bacampicillin Side Effects
Applies to bacampicillin: oral tablet
Besides the urticarial rash of hypersensitivity to bacampicillin, a delayed hypersensitivity maculopapular rash may occur 10 to 12 days after bacampicillin therapy is begun.
Hypersensitivity reactions occur in up to 5% of patients treated with bacampicillin. Such reactions may include urticarial rashes, edema, hypotension, fever, eosinophilia, Stevens-Johnson syndrome, and dyspnea. Anaphylaxis is rare. Bacampicillin should not be given to patients with a penicillin allergy.[Ref]
Gastrointestinal adverse effects occur in 2% to 5% of treated patients and may include diarrhea, nausea, vomiting, and abdominal cramps. Rare cases of hepatitis and pancreatitis have been reported with ampicillin, the active form of bacampicillin. Monitoring of liver function tests is recommended in patients with liver dysfunction.[Ref]
Bacampicillin-associated diarrhea is usually self-limited and is likely related to alterations in the intestinal microflora. Such alterations may predispose patients to the development of diarrhea from Clostridium difficile toxin. Rare cases of transiently increased liver function tests and chronic cholestasis associated with ampicillin have been reported.
Acute pancreatitis associated with ampicillin has been reported and confirmed by rechallenge with ampicillin in a patient with no other obvious cause of pancreatitis.[Ref]
Hematologic adverse effects of bacampicillin are rare and include thrombocytopenia, red cell aplasia, and anemia.[Ref]
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8. Hughes GS "Ampicillin and hematologic effects." Ann Intern Med 99 (1983): 573
9. "Product Information. Spectrobid (bacampicillin)." Roerig Division, New York, NY.
Some side effects may not be reported. You may report them to the FDA.