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Axert Side Effects

Generic name: almotriptan

Medically reviewed by Last updated on Jun 14, 2023.

Note: This document contains side effect information about almotriptan. Some dosage forms listed on this page may not apply to the brand name Axert.

Applies to almotriptan: oral tablet.

Serious side effects of Axert

Along with its needed effects, almotriptan (the active ingredient contained in Axert) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking almotriptan:

Less common


Other side effects of Axert

Some side effects of almotriptan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to almotriptan: oral tablet.


The most common adverse reactions in adults included nausea, dry mouth, and paresthesia. The most common adverse reactions in adolescents included dizziness, somnolence, headache, paresthesia, nausea, and vomiting.[Ref]


Uncommon (0.1% to 1%): Chest pain, vasodilation, palpitations, tachycardia

Rare (less than 0.1%): Hypertension, syncope

Frequency not reported: Coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia, ventricular fibrillation, sensation of pain, tightness, pressure in the chest and/or throat, neck and jaw, peripheral vascular ischemia

Postmarketing reports: Acute myocardial infarction, coronary artery vasospasm, angina pectoris, tachycardia[Ref]

At least 1 case of coronary vasospasm has been reported in a patient with no cardiac history and with documented absence of coronary artery disease (CAD) following administration of this drug. During clinical trials (n=3865), a 48-year old female patient who had previously taken 3-doses for earlier migraine attacks was hospitalized after an ECG found negative T-waves on the left leads 48 hours after receiving almotriptan 6.25 mg. Myocardial enzymes were normal. The patient had a family history of CAD. A coronary angiography and an ECG done 2 days later were normal.

Mean increases in systolic and diastolic blood pressure were observed in normotensive healthy subjects (0.21 and 1.35 mmHg) and patients with hypertension controlled by medication (4.87 and 0.26 mmHg), respectively, over the first 4 hours after receiving almotriptan 12.5 mg.[Ref]

Nervous system

Common (1% to 10%): Somnolence, headache, paresthesia, dizziness

Uncommon (0.1% to 1%): Tremor, hypoesthesia, CNS stimulation, shakiness

Rare (less than 0.1%): Impaired concentration, abnormal coordination, hyperreflexia, hypertonia, neuropathy, nystagmus, insomnia, parosmia, taste alteration

Postmarketing reports: Hemiplegia, hypoesthesia, seizures[Ref]


Common (1% to 10%): Nausea, dry mouth, vomiting

Uncommon (0.1% to 1%): Abdominal cramp or pain, diarrhea, dyspepsia, gastroenteritis, increased thirst

Rare (less than 0.1%): Colitis, gastritis, esophageal reflux, increased salivation

Frequency not reported: Colonic ischemia

Postmarketing reports: Abdominal discomfort, abdominal pain, upper abdominal pain, colitis, hypoesthesia oral, swollen tongue[Ref]


Postmarketing reports: Hypersensitivity reactions including angioedema, anaphylactic reactions and anaphylactic shock[Ref]


Uncommon (0.1% to 1%): Neck pain, rigid neck, back pain, myalgia, bone pain

Rare (less than 0.1%): Arthralgia, arthritis, myopathy, muscle weakness

Postmarketing reports: Arthralgia, myalgia, extremity pain[Ref]


Uncommon (0.1% to 1%): Pharyngitis, rhinitis, dyspnea, laryngismus, sinusitis, bronchitis, throat tightness

Rare (less than 0.1%): Hyperventilation, laryngitis, sneezing, epistaxis[Ref]


Uncommon (0.1% to 1%): Asthenia, chills, fatigue, ear pain, tinnitus

Rare (less than 0.1%): Fever, otitis media, hyperacusis

Postmarketing reports: Malaise, peripheral coldness, vertigo[Ref]


Uncommon (0.1% to 1%): Dysmenorrhea[Ref]


Uncommon (0.1% to 1%): Anxiety, restlessness

Rare (less than 0.1%): Changes in dreams, depressive symptoms, euphoria, nervousness, nightmares, insomnia

Postmarketing reports: Confusional state, restlessness[Ref]


Uncommon (0.1% to 1%): Hyperglycemia, increased serum creatine phosphokinase

Rare (less than 0.1%): Hypercholesterolemia[Ref]


Rare (less than 0.1%): Increased gamma glutamyl transpeptidase[Ref]


Rare (less than 0.1%): Diplopia, dry eyes, eye pain, scotoma, conjunctivitis, eye irritation

Postmarketing reports: Blepharospasm, visual impairment, blurred vision[Ref]


Uncommon (0.1% to 1%): Diaphoresis, pruritus, rash

Rare (less than 0.1%): Photosensitivity reaction, dermatitis, erythema

Postmarketing reports: Cold sweat, erythema, hyperhidrosis[Ref]


Postmarketing reports: Breast pain[Ref]


1. (2001) "Product Information. Axert (almotriptan)." Pharmacia and Upjohn

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.