Generic Name: almotriptan (AL moe TRIP tan)
Brand Name: Axert
What is Axert (almotriptan)?
Almotriptan is a headache medicine that narrows blood vessels around the brain. Almotriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.
Almotriptan is used to treat migraine headaches in adults and in adolescents who are at least 12 years old. Almotriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.
Almotriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use this medicine only if your condition has been confirmed by a doctor as migraine headaches.
Almotriptan may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Axert (almotriptan)?
You should not take almotriptan if you have ever had heart disease, or if you have coronary artery disease, blood circulation problems, lack of blood supply to the heart, uncontrolled high blood pressure, ischemic bowel disease, a history of a heart attack or stroke (including "mini-stroke"), or if your headache seems to be different from your usual migraine headaches.
Do not take almotriptan within 24 hours before or after using another migraine headache medicine, including other "triptan" medications, or an ergot medicine such as dihydroergotamine, ergotamine, ergonovine, methylergonovine, D.H.E. 45, Migranal, Cafergot, Methergine, and others.
What should I discuss with my healthcare provider before using Axert (almotriptan)?
You should not take almotriptan if you are allergic to it, or if you have:
a history of heart disease;
a history of heart attack or stroke, including "mini-stroke";
coronary artery disease, circulation problems, lack of blood supply to the heart;
uncontrolled high blood pressure;
ischemic bowel disease; or
a headache that seems different from your usual migraine headaches.
To make sure almotriptan is safe for you, tell your doctor if you have:
a sulfa drug allergy;
high blood pressure, a heart rhythm disorder; or
risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).
FDA pregnancy category C. It is not known whether almotriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
It is not known whether almotriptan passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to anyone under 12 years old.
How should I take Axert (almotriptan)?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Never use more than your recommended dose. Overuse of migraine headache medicine can make headaches worse. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks.
Your doctor may want to give your first dose of this medicine in a clinic setting to quickly treat any serious side effects that occur.
Take almotriptan as soon as you notice headache symptoms, or after an attack has already begun.
After taking a tablet: If your headache goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than two (2) almotriptan tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.
If your headache does not completely go away after taking the first tablet, call your doctor before taking any more tablets.
Contact your doctor if you have more than four headaches in one month (30 days).
If you use almotriptan long-term, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Since almotriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using almotriptan.
After taking an almotriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than two (2) almotriptan tablets in 24 hours.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose could cause high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, or seizure).
What should I avoid while using Axert (almotriptan)?
Do not take almotriptan within 24 hours before or 24 hours after using another migraine headache medicine, including:
eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, Treximet), zolmitriptan (Zomig); or
ergot medicine such as dihydroergotamine, ergotamine, ergonovine, methylergonovine, D.H.E. 45, Migranal, Cafergot, Methergine, and others.
Almotriptan may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Axert (almotriptan) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using almotriptan and call your doctor at once if you have:
numbness or tingling and a pale or blue-colored appearance in your fingers or toes;
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting;
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; or
dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats, seizure.
Common side effects may include:
numbness, tingling, or burning sensation;
dizziness, drowsiness; or
mild headache (not a migraine).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Axert (almotriptan)?
Tell your doctor about all medicines you have used within the past 14 days, and all medicines you start or stop using during your treatment with almotriptan, especially:
antifungal medicine--itraconazole, ketoconazole;
an MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others;
an SNRI antidepressant--desvenlafaxine (Pristiq), duloxetine (Cymbalta), venlafaxine (Effexor); or
an SSRI antidepressant--citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, trazodone, vilazodone, Celexa, Desyrel, Lexapro, Luvox, Paxil, Prozac, Sarafem, Symbyax, Viibryd, Zoloft.
This list is not complete. Other drugs may interact with almotriptan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Axert (almotriptan)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about almotriptan.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 10.01.
Last reviewed: October 09, 2014
Date modified: October 14, 2016