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Aminoxin Side Effects

Generic Name: pyridoxine

Note: This page contains information about the side effects of pyridoxine. Some of the dosage forms included on this document may not apply to the brand name Aminoxin.

For the Consumer

Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release

In addition to its needed effects, some unwanted effects may be caused by pyridoxine (the active ingredient contained in Aminoxin). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:

With large doses
  • Clumsiness
  • numbness of hands or feet

For Healthcare Professionals

Applies to pyridoxine: compounding powder, injectable solution, oral capsule, oral tablet

Nervous system

The profound sensory loss following treatment with high doses of parenteral pyridoxine (the active ingredient contained in Aminoxin) may not be reversible.[Ref]

Nervous system side effects have included sensory neuropathy with axonal degeneration. The adverse neurologic side effects have been reported following a single large dose (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses. Peripheral sensory neuropathy has also been reported.[Ref]


Hypersensitivity side effects have been reported rarely.[Ref]


Dermatologic side effects have included allergic contact dermatitis. Photosensitivity has been confirmed in a female patient taking pyridoxine (the active ingredient contained in Aminoxin) 100 mg orally daily.[Ref]


1. Albin RL, Albers JW "Long-term follow-up of pyridoxine-induced acute sensory neuropathy- neuronopathy." Neurology 40 (1990): 1319

2. "Multum Information Services, Inc. Expert Review Panel"

3. Morimoto K, Kawada A, Hiruma M, Ishibashi A "Photosensitivity from pyridoxine hydrochloride (vitamin b-6)." J Am Acad Dermatol 35 (1996): 304-5

4. Camarasa JG, Serra-Baldrich E, Lluch M "Contact allergy to vitamin B6." Contact Dermatitis 23 (1990): 115

Not all side effects for Aminoxin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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