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Akynzeo for Injection Side Effects

Generic name: fosnetupitant / palonosetron

Medically reviewed by Drugs.com. Last updated on Jan 11, 2021.

Note: This document contains side effect information about fosnetupitant / palonosetron. Some of the dosage forms listed on this page may not apply to the brand name Akynzeo for Injection.

For the Consumer

Applies to fosnetupitant/palonosetron: intravenous powder for solution, intravenous solution

Side effects requiring immediate medical attention

Along with its needed effects, fosnetupitant / palonosetron may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fosnetupitant / palonosetron:

Incidence not known

  • Agitation
  • confusion
  • cough or hoarseness
  • dizziness
  • fast heartbeat
  • fever
  • hearing or seeing things that are not there
  • hives, itching, skin rash
  • irritation
  • joint pain, stiffness or swelling
  • muscle twitching
  • overactive reflexes
  • poor coordination
  • redness of the skin
  • shivering
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • trembling or shaking
  • trouble breathing or swallowing

Side effects not requiring immediate medical attention

Some side effects of fosnetupitant / palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Headache
  • unusual tiredness or weakness

Less common

For Healthcare Professionals

Applies to fosnetupitant / palonosetron: intravenous powder for injection

Gastrointestinal

Frequency not reported: Constipation, dyspepsia

Palonosetron:

Common (1% to 10%): Constipation, dyspepsia[Ref]

Other

Frequency not reported: Asthenia, fatigue

Palonosetron:

Common (1% to 10%): Asthenia, fatigue[Ref]

Nervous system

Frequency not reported: Headache, serotonin syndrome

Palonosetron:

Common (1% to 10%): Headache[Ref]

Dermatologic

Frequency not reported: Erythema

Palonosetron:

Common (1% to 10%): Erythema[Ref]

Hepatic

Palonosetron:

Uncommon (0.1% to 1%): Elevated AST, elevated ALT, elevated total bilirubin[Ref]

Approximately 0.6% of patients given 0.5 mg of palonosetron developed AST greater than 3 times the upper limit of normal (ULN) and/or ALT greater than 3 x ULN with total bilirubin greater than ULN. Approximately 0.2% of patients given the same dose of palonosetron developed AST greater than 10 x ULN and/or ALT greater than 10 x ULN with total bilirubin greater than ULN, and approximately 0.1% of patients developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN.

Approximately 0.3% of patients given oral formulations of netupitant-palonosetron developed AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than ULN, and AST greater than 3 x ULN and/or ALT greater than 3 x ULN with total bilirubin greater than or equal to 2 x ULN occurred in up to 0.1% of patients.[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions[Ref]

References

1. "Product Information. Akynzeo for Injection (fosnetupitant-palonosetron)." Helsinn Therapeutics Inc, Woodbridge Township, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.