Aggrastat Side Effects

Generic name: tirofiban

Medically reviewed by Drugs.com. Last updated on Jun 29, 2024.

Note: This document provides detailed information about Aggrastat.

Applies to tirofiban: intravenous solution Side Effects associated with tirofiban. Some dosage forms listed on this page may not apply specifically to the brand name Aggrastat.

Applies to tirofiban: intravenous solution.

Precautions

It is very important that your doctor check you at regular visits after you leave the hospital for any problems that may be caused by this medicine. Blood and urine tests will be needed to check for unwanted effects. Be sure to keep all appointments.

You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off.

Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Avoid picking your nose. If you need to blow your nose, blow it gently.

You may be told to use a soft toothbrush or to shave with an electric razor (not a razor blade) for a few days after you have been given this medicine. This helps reduce the risk of bleeding.

Watch for any bleeding from open areas such as sites of needle punctures for drawing blood, giving shots, or putting in a catheter for a heart catheterization or angioplasty. Also check for blood in your urine or bowel movements. If you have any bleeding or injuries, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Aggrastat

Along with its needed effects, tirofiban (the active ingredient contained in Aggrastat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tirofiban:

Other side effects of Aggrastat

Some side effects of tirofiban may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to tirofiban: intravenous powder for injection, intravenous solution.

General adverse events

Bleeding is the most common adverse reaction. Clinical trial adverse reactions were reported in patients taking this drug in addition to heparin.^[Ref]

Hematologic

• Very common (10% or more): Thrombolysis in myocardial infarction (TIMI) minor bleeding (up to 10.5%)
• Common (1% to 10%): TIMI major bleeding, transfusions, platelets decreased to less than 90,000 cells/mm3
• Uncommon (0.1% to 1%): Platelets decreased to less than 50,000 cells/mm3
• Postmarketing reports: Platelets decreased to less than 10,000 cells/mm3, fatal bleeding^[Ref]

Nervous system

• Common (1% to 10%): Vasovagal reaction, dizziness, headache
• Postmarketing reports: Intracranial bleeding^[Ref]

Cardiovascular

• Common (1% to 10%): Bradycardia, coronary artery dissection
• Postmarketing reports: Hemopericardium^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea
• Postmarketing reports: Retroperitoneal bleeding^[Ref]

Other

• Common (1% to 10%): Edema/swelling
• Postmarketing reports: Spinal epidural hematoma^[Ref]

Dermatologic

• Common (1% to 10%): Sweating^[Ref]

Genitourinary

• Common (1% to 10%): Pelvic pain^[Ref]

Musculoskeletal

• Common (1% to 10%): Leg pain^[Ref]

Immunologic

• Postmarketing reports: Severe allergic reactions, anaphylactic reactions^[Ref]

Respiratory

• Postmarketing reports: Pulmonary hemorrhage^[Ref]

See also:

Further information

Aggrastat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer