Skip to Content

Aggrastat Side Effects

Generic Name: tirofiban

Note: This page contains information about the side effects of tirofiban. Some of the dosage forms included on this document may not apply to the brand name Aggrastat.

For the Consumer

Applies to tirofiban: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by tirofiban (the active ingredient contained in Aggrastat). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking tirofiban, check with your doctor or nurse immediately:

More common:
  • Abdominal or stomach pain or swelling
  • arm, back, or jaw pain
  • black, tarry stools
  • blood in the eyes
  • blood in the urine
  • bruising or purple areas on the skin
  • chest pain or discomfort
  • chest tightness or heaviness
  • coughing up blood
  • decreased alertness
  • fast or irregular heartbeat
  • headache
  • joint pain or swelling
  • nausea
  • nosebleeds
Less common:
  • Bleeding gums
  • lightheadedness or fainting
  • pinpoint red spots on the skin
  • severe, unusual tiredness or weakness
  • slow heartbeat
  • swelling of the hands, ankles, feet, or lower legs
Incidence not known:
  • Chills or fever
  • cough
  • difficulty swallowing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash, hives, or itching
  • trouble breathing

Minor Side Effects

Some of the side effects that can occur with tirofiban may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Pain in the legs or hips
Less common:
  • Dizziness
  • sweating

For Healthcare Professionals

Applies to tirofiban: intravenous powder for injection, intravenous solution


Bleeding is the most common adverse reaction. Clinical trial adverse reactions were reported in patients taking this drug in addition to heparin.[Ref]


Very common (10% or more): Thrombolysis in myocardial infarction (TIMI) minor bleeding (up to 10.5%)
Common (1% to 10%): TIMI major bleeding, transfusions, platelets decreased to less than 90,000 cells/mm3
Uncommon (0.1% to 1%): Platelets decreased to less than 50,000 cells/mm3
Postmarketing reports: Platelets decreased to less than 10,000 cells/mm3, fatal bleeding[Ref]

Nervous system

Common (1% to 10%): Vasovagal reaction, dizziness, headache
Postmarketing reports: Intracranial bleeding[Ref]


Common (1% to 10%): Bradycardia, coronary artery dissection
Postmarketing reports: Hemopericardium[Ref]


Common (1% to 10%): Nausea
Postmarketing reports: Retroperitoneal bleeding[Ref]


Common (1% to 10%): Edema/swelling
Postmarketing reports: Spinal epidural hematoma[Ref]


Common (1% to 10%): Sweating[Ref]


Common (1% to 10%): Pelvic pain[Ref]


Common (1% to 10%): Leg pain[Ref]


Postmarketing reports: Severe allergic reactions, anaphylactic reactions[Ref]


Postmarketing reports: Pulmonary hemorrhage[Ref]


1. "Product Information. Aggrastat (tirofiban)." Merck & Co, Inc, West Point, PA.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Aggrastat may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.