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Advil Multi-Symptom Cold & Flu Side Effects

Generic name: chlorpheniramine / ibuprofen / phenylephrine

Medically reviewed by Drugs.com. Last updated on Jun 6, 2022.

Note: This document contains side effect information about chlorpheniramine / ibuprofen / phenylephrine. Some of the dosage forms listed on this page may not apply to the brand name Advil Multi-Symptom Cold & Flu.

Applies to chlorpheniramine / ibuprofen / phenylephrine: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, chlorpheniramine / ibuprofen / phenylephrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorpheniramine / ibuprofen / phenylephrine:

Incidence not known

  • Bloody or black, tarry stools
  • chest pain or tightness
  • confusion
  • constipation
  • cough
  • decrease urine output
  • diarrhea
  • difficulty in speaking
  • difficulty swallowing
  • dilated neck veins
  • dizziness
  • double vision
  • fast heartbeat
  • headache
  • heartburn
  • hives, itching, skin rash
  • inability to speak
  • inability to move the arms, legs, or facial muscles
  • indigestion
  • irregular breathing
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe stomach pain, cramping, or burning
  • swelling of the face, fingers, feet, or lower legs
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weight gain

Side effects not requiring immediate medical attention

Some side effects of chlorpheniramine / ibuprofen / phenylephrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Nervousness
  • trouble sleeping
  • unusual excitement, especially in children

More about Advil Multi-Symptom Cold & Flu (chlorpheniramine / ibuprofen / phenylephrine)

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.