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Abiraterone Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 30, 2022.

Summary

Commonly reported side effects of abiraterone include: decreased serum potassium, increased serum aspartate aminotransferase, increased serum triglycerides, fluid retention, and hypokalemia. Other side effects include: hypertension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to abiraterone: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, abiraterone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking abiraterone:

More common

  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • body aches or pain
  • chills
  • cough
  • decreased urine
  • difficult, burning, or painful urination
  • dizziness
  • dry mouth
  • ear congestion
  • fainting
  • fast, slow, or irregular heartbeat
  • fever
  • fractures
  • frequent urge to urinate
  • headache
  • increased thirst
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • mood changes
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • nervousness
  • pounding in the ears
  • runny or stuffy nose
  • seizures
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • swelling
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Chest pain, discomfort, or tightness
  • dilated neck veins
  • irregular breathing
  • weight gain

Incidence not known

  • Clay-colored stools
  • dark urine
  • diarrhea
  • general feeling of discomfort or illness
  • itching, rash
  • muscle cramp, spasm, pain, or stiffness
  • stomach pain, continuing
  • thickening of bronchial secretions
  • unpleasant breath odor
  • vomiting of blood
  • yellow eyes or skin

Side effects not requiring immediate medical attention

Some side effects of abiraterone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • falls
  • feeling of warmth
  • groin pain
  • increased urge to urinate during the night
  • joint swelling or discomfort
  • redness of the face, neck, arms, and occasionally, upper chest
  • trouble sleeping
  • waking to urinate at night

For Healthcare Professionals

Applies to abiraterone: oral tablet

Endocrine

Uncommon (0.1% to 1%): Adrenocortical insufficiency[Ref]

Hepatic

Very common (10% or more): Elevated ALT (up to 41.9%), elevated AST (up to 37.3%)

Common (1% to 10%): Elevated total bilirubin

Postmarketing reports: Fulminant hepatitis, acute liver failure and death[Ref]

Cardiovascular

Very common (10% or more): Hot flush (up to 22.3%), hypertension (up to 21.6%)

Common (1% to 10%): Arrhythmia, chest pain/chest discomfort, angina pectoris, atrial fibrillation, tachycardia, myocardial infarction/ischemia, cardiac failure (e.g., congestive heart failure, left ventricular dysfunction, decreased ejection fraction)

Frequency not reported: QT prolongation[Ref]

Musculoskeletal

Very common (10% or more): Joint swelling/discomfort (up to 30.3%), muscle discomfort (up to 26.2%), contusion (up to 13.3%)

Common (1% to 10%): Groin pain, fractures, falls

Postmarketing reports: Rhabdomyolysis, myopathy[Ref]

Hematologic

Very common (10% or more): Lymphopenia (up to 38.2%), anemia[Ref]

Metabolic

Very common (10% or more): Hypertriglyceridemia (up to 62.5%), hyperglycemia (up to 56.6%), hypernatremia (up to 32.8%), hypokalemia (up to 28.3%), fluid retention/edema (up to 26.7%), hypophosphatemia (up to 23.8%), elevated alkaline phosphatase, hypercholesterolemia[Ref]

Renal

Frequency not reported: Renal failure[Ref]

Other

Very common (10% or more): Fatigue (up to 39.1%)

Common (1% to 10%): Sepsis, pyrexia[Ref]

Respiratory

Very common (10% or more): Cough (up to 17.3%), upper respiratory tract infection (up to 12.7%), dyspnea (up to 11.8%), nasopharyngitis (up to 10.7%)

Postmarketing reports: Non-infectious pneumonitis, allergic alveolitis[Ref]

Genitourinary

Very common (10% or more): Urinary tract infection (up to 12%), hematuria (up to 10.3%)

Common (1% to 10%): Urinary frequency, nocturia[Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 13.5%)[Ref]

Gastrointestinal

Very common (10% or more): Constipation (up to 23.1%), diarrhea (up to 21.6%), dyspepsia (up to 11.1%), vomiting[Ref]

Dermatologic

Common (1% to 10%): Rash[Ref]

Frequently asked questions

References

1. "Product Information. Zytiga (abiraterone)." Centocor Inc (2011):

2. "Product Information. Yonsa (abiraterone)." Sun Pharmaceutical Industries (2018):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.