Skip to Content

The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Orphenadrine Citrate / Aspirin / Caffeine

Pronunciation: ore-FEN-uh-dreen SIH-trate/ASS-pihr-in/kaff-EEN
Class: Skeletal muscle relaxant

Trade Names

Orphenadrine Compound
- Tablets 25 mg orphenadrine citrate per 385 mg aspirin per 30 mg caffeine

Orphenadrine Compound-DS
- Tablets 50 mg orphenadrine citrate per 770 mg aspirin per 60 mg caffeine



May be related to analgesic properties.


Inhibits prostaglandin synthesis, resulting in analgesia, anti-inflammatory activity, and inhibition of platelet aggregation.


Is thought to produce constriction of cerebral blood vessels.

Indications and Usage

Symptomatic relief of mild to moderate pain of acute musculoskeletal disorders; adjunct to rest, physical therapy, and other measures for the relief of discomfort with acute painful musculoskeletal conditions.


Patients with glaucoma, pyloric or duodenal obstruction, achalasia (eg, failure of visceral openings or sphincter muscle to relax), prostatic hypertrophy or obstructions at the bladder neck, myasthenia gravis; hypersensitivity to any component of the product.

Dosage and Administration


PO Orphenadrine Compound 1 to 2 tablets 3 to 4 times daily; Orphenadrine Compound-DS ½ to 1 tablet 3 to 4 times daily.


Store below 86°F. Protect from moisture.

Drug Interactions

Anticoagulants (eg, warfarin)

Effects of anticoagulants may be enhanced by aspirin, increasing the risk of bleeding.

Uricosuric agents (probenecid)

Effects may be inhibited by aspirin.

Adverse Reactions


Tachycardia; palpitation.


Weakness; confusion; excitation; hallucinations; headache; lightheadedness; dizziness; syncope.


Urticaria and other dermatoses.


Blurred vision; dilation of the pupil; increased intraocular tension; drowsiness.


Dry mouth; nausea; vomiting; hemorrhage.


Urinary hesitancy or retention; constipation.



Safety and efficacy not established.




Safety and efficacy not established.

Reye syndrome

Has been associated with aspirin administration to children (including teenagers) with acute febrile illness.

Peptic ulcers

Use with extreme caution.

Patient Information

  • Advise patient to take prescribed dose 3 to 4 times daily if needed for muscle pain, muscle spasm, or limited mobility.
  • Advise patient to take without regard to meals but to take with food if GI upset occurs.
  • Instruct patient to avoid alcoholic beverages and other depressants while taking this medication.
  • Advise patient that drug may cause drowsiness, dizziness, or blurred vision and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
  • Advise patient to stop taking the drug and notify health care provider if any of the following occur: allergic reaction, unusual bleeding or bruising, shortness of breath, black or tarry stools, vomiting of blood or coffee ground-like material.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.